The cytotoxic activity of ethanolic extracts of Thymus vulgaris, Thuja orientalis and Achillea millefolium was investigated on various growing tumor cell lines. MTT colorimetric assay was used for measuring the inhibition of cell proliferation. All of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (SK-Br-3, MDA-MB-435) and leukemia ...

Recently discovered subpopulations belonging to cell groups called “invariant” NKT, also referred as type I NKT or classical cells, appear have a unique impact on the tumor microenvironment. Considering characteristics of secreted cytokines, production chemokines and capability cytotoxic activity, these cells significant function in being immune bacteria, parasites, viruses, autoimmune diseases...

Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...

Tumor immunotherapy is currently a hot research topic in the field of oncology, and an efficacious mode tumor treatment. Programmed cell death receptor PD-1 (PD-1) important immunosuppressive molecule, which mainly expressed activated T B cells. PD-1/PD-L1 inhibitors can block binding to PD-L1, negative regulatory signals, restore activity cells, thus enhancing immune response.

abstract background: asterocytoma is the most common primary human brain tumor which has the most lethal hazard among tumors in human central nervous system. heat shock proteins play an active role in cancer cells pathways through their effects on tumor cell proliferation, tumor differentiation, malignancy, metastasis, and cell death. hsp 70 is a 70 kd protein that its expression change has bee...