Cystic formation in human primary brain tumors is a relatively rare event whose incidence varies widely according to the histotype of tumor. Composition cystic fluid has mostly been characterized samples collected at time tumor resection and no indications evolution content are available. We proteome using bottom-up proteomic approach on sequential obtained from secretory meningioma (SM), schwa...

Although cell-in-cell structures (CICs) could be detected in a wide range of human tumors, homotypic CICs formed between tumor cells occur at low rate for most of them. We recently reported that tumor cells lacking expression of E- and P-cadherin were incapable of forming homotypic CICs by entosis, and re-expression of E- or P-cadherin was sufficient to induce CICs formation in these tumor cell...

Introduction: CSCs have been identified in prostate cancer (PCa), one of the most diagnosed malignancies in men over the world, for which radiation resistance is a major problem in the treatment of advanced stages. Cancer stem cells (CSCs) have the ability to self-renew and differentiate to give rise to heterogeneous phenotype of the tumor cells. It is believed that CSCs are ...

Abstract Biomechanics is a fundamental feature of cell. However, the manner by which actomysin tension affects tumor immune evasion remains unclear. Here we show that although cytotoxic T lymphocytes (CTL) can effectively destroy stiff differentiated cells, they fail to kill soft tumor-repopulating cells (TRC). TRC softness prevented membrane pore formation caused CTL-released perforin. Perfori...

We generated a mouse strain lacking protein kinase Calpha (PKCalpha) and evaluated the significance of the enzyme in epithelial hyperplasia and tumor formation. PKCalpha-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12-dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetrade...

We generated a mouse strain lacking protein kinase CA (PKCA) and evaluated the significance of the enzyme in epithelial hyperplasia and tumor formation. PKCA-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol...

brown tumors may occur secondary to hyperparathyroidism in patients with chronic renal failure (ckd). they are increasingly rare because hyperparathyroidism in now diagnosed and treated at an early stage. we report 67-year-old man who had been on hemodialysis for crf for over 3 years, who presented with back pain over the thoracolumbar junction from 2 years ago and because of pain he could not ...

An increased expression of focal adhesion kinase (FAK) in a variety of cancers is associated with a poor disease prognosis. To study the role of FAK in breast tumor growth and metastasis formation, we used conditional doxycycline-regulated expression of a dominant-negative acting splice variant of FAK, FAK-related non-kinase (FRNK), in MTLn3 mammary adenocarcinoma cells in a syngeneic Fischer 3...

Renewable neurosphere formation in culture is a defining characteristic of certain brain tumor initiating cells. This retrospective study was designed to assess the relationship among neurosphere formation in cultured human glioma, tumorigenic capacity, and patient clinical outcome. Tumor samples were cultured in neurosphere conditions from 32 patients with glioma, including a subpopulation of ...

background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...