Prostate cancer is relatively unique to man. There is no naturally occurring prostate cancer in the mouse. Pre-clinical studies involve the establishment of a genetically engineered mouse prostate cancer model with features close to those of the human situation. A new knock-in mouse adenocarcinoma prostate (KIMAP) model was established, which showed close-to-human kinetics of tumor development....

Background: Breast cancer is the most commonly diagnosed and the leading cause of cancer death among females worldwide. The rate of breast cancer incidence among Iranian women is 17% of all cancers, it has been ranked first in Iran. This study aimed to investigate the factors affecting axillary lymph node involvement in female patients with breast cancer. Methods: A cross-sectional study was c...

The grade of clear cell renal carcinoma (ccRCC) is a critical prognostic factor, making ccRCC nuclei grading crucial task in RCC pathology analysis. Computer-aided aims to improve pathologists’ work efficiency while reducing their misdiagnosis rate by automatically identifying the grades tumor within histopathological images. Such requires precisely segment and accurately classify nuclei. Howev...

In the present study, important parameters like frequency distribution of Gliomas, age group Glioma patients, common sex involved, commonest site occurrence, clinical presentations, radiological histopathological correlation, p16INK4a expression glial tumors are compared with other similar studies. The aim is to find out occurrence and it includes higher grades Astrocytomas. study focuses on sy...

Histological grading quantifies the tumor architecture and cytology deviation of breast cancer against normal tissue. Nottingham Grading System grades classification allots scores. Mitotic detection is one major components in System. Using a conventional microscope time-consuming, semi-quantitative has limited histological parameters. Digital scanners scan tissue slice into high-resolution virt...

background pancreatic neuroendocrine tumors (pnets) are rare tumors with variable malignant potential, prognosis, and survival. we aimed to assess the characteristics of patients with non- functional pnet  in our hospital . methods from nov 2010 to nov 2013 , all patients who came to endosonography unit of shariati  hospital , tehran , iran , and   had pancreatic lesions were assessed . tumor s...

  Objective: To review Her-2/neu and Tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. Materials and Methods: This cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between May 2000 and March 2006 at the surgery and pathology departments of Alzahra Hosp...