It has been reported that ectopically expressed interleukin-17 (IL-17) in tumor cells suppresses tumor progression through enhanced antitumor immunity in immune competent mice or promote tumor progression through an increase in inflammatory angiogenesis in immune-deficient mice. The role of endogenous IL-17 in tumor immunity remains undefined. Here we showed that tumor growth and lung metastasi...

The importance of immunoregulatory T cells has become increasingly apparent. Both CD4+CD25+ T cells and CD1d-restricted NKT cells have been reported to down-regulate tumor immunity in mouse tumor models. However, the relative roles of both T cell populations have rarely been clearly distinguished in the same tumor models. In addition, CD1d-restricted NKT cells have been reported to play a criti...

The effects of carrageenan and trypan blue on the expression of adoptive immunity to the syngeneic guinea pig line 10 hepatoma were investigated. Adoptive immunity was assessed by observing dermal tumor growth in recipients of immune cells and by bioassays in which tumor challenge sites were transplanted into secondary hosts. Carrageenan abrogated transferred immunity in treated animals as evid...

Abstract Gut microbiota is now recognized as a key player impacting the host’s anti-cancer immunosurveillance and ability to respond immunotherapy. Its optimal modulation for preventive therapeutic purposes very appealing. Since diet one of most powerful modulators microbiota, nutritional interventions could be leveraged improve host immunity. The present study aims analyze anticancer propertie...

It was shown that the progressive growth of the immunogenic meth A fibrosarcoma in its semisyngeneic host results in the generation of concomitant immunity to the growth of a tumor implant. The generation of immunity occurred between days 6 and 9 of tumor growth and was associated with the generation of sensitized T cells that were capable, on passive transfer, of causing regression of a 3-d tu...

Failure of current therapies to eliminate tumors is, in part, due inadequate infiltration immune cells. The importance endothelial cells for the induction responses is now being recognized. However, tumor (TECs) are dysfunctional, leading decreased immunity. Because TEC metabolism contributes abnormal vascular phenotype, interest growing vasculature as a target improve responses. Recent insight...

Antitumor activity of Lactobacillus casei YIT 9018 ( LC9018 ) was studied in BALB/c mice by using two syngeneic tumors; methylcholanthrene-induced tumor (Meth A fibrosarcoma) and Kirstein murine sarcoma virus-transformed BALB/3T3 ( K234 tumor). Administration of an LC9018 -Meth A cell mixture induced complete suppression of the tumor growth, while simultaneous injections of LC9018 and Meth A ce...

Radiotherapy is a standard treatment for cancer and is used since a long time as a stand-alone therapy or in combination with surgery and systemic therapies including immunotherapy. Its acts through induction of irreversible DNA damage to which tumor cells are more susceptible because of frequent mutations in DNA repair pathways. Fractioned radiotherapy, given as daily low doses during multiple...

We have previously shown that B7-2 (CD86)-transfected P815 tumor cells elicit tumor-eradicating immunity that leads to the regression of the B7-2+ P815 tumor after transient growth in normal DBA/2 mice. Here, we show that both the B7-2 and B7-1 (CD80) molecules contribute to the eradication of B7-2+ P815 tumors as treatment of the mice with both anti-B7-2 and anti-B7-1 mAb was required to preve...