Abstract Background Malignant brain tumors are the cause of a disproportionate level morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in molecular characterization these tumors, targeting cells yet to produce significant treatment. An alternative strategy is target glioblastoma microenvironment, such as...

Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with progression tumors and worse prognosis many cancers, namely on cervical cancer. This work exhaustively summarizes conclusions different studies published concerning TAMs function cancer, from vitro using cell lines to clinical perspective (histo...

Tumor immune microenvironment has been shown to be important in predicting the tumor progression and outcome of treatments. This work aims identify different patterns osteosarcoma their clinical characteristics. We use latest best performing deconvolution method, CIBERSORTx, obtain relative abundance 22 cells. Then we cluster patients based on estimated study characteristics these clusters, alo...

The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as...

Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are...

The evolutionary path from tumor initiation to metastasis can only be fully understood by considering cancer cells as part of a multi-species ecosystem within the tumor microenvironment. This paper reviews and suggests two important recent trends. Firstly, I review arguments that interactions among diverse cells in the tumor microenvironment create a distinct cellular environment that can confe...