The acidity constants of eight macrolides (erythromycin, roxithromycin, oleandomycin, azithromycin, josamycin, tylosin tartrate, tilmicosin and spiramycin) have been determined in acetonitrile-water binary mixtures (30%, 40% and 50% (v/v)) by spectrophotometric method. The pKa's available in literature determined by various methods are compiled in comparison with the value of this work. These r...

A total of 210 twenty twoday-old broiler chicks were used in this programme to investigale the performance, [ca\ intake, digestibility and visceral organ mass of broiler chicks fed with high level of olive pulp.supplemented with two antibiotics: streptomycin and tylosin. The two antibiotics were added to supply 150 nig/kg of the active ingredient. Chicks which consumed the medicated diets had m...

The tlrB gene from Streptomyces fradiae has been cloned and used to construct bifunctional Streptomyces-Escherichia coli shuttle vectors carrying the antibiotic resistance genes to kanamycin-neomycin, thiostrepton and tylosin as selection markers. In the same way, the tlrB gene was subcloned in plasmids including the apramycin resistance gene and the oriT sequence from the plasmid pSET152 to fa...

The studies were carried out in a breeding turkey flock in which mycoplasma infections were detected (serologically and by isolation from semen). Trials using tylosin and enrofloxacin were carried out to limit the infection. The antibiotics were given to the birds for 5 days in therapeutic doses and to semen at concentration of 1 mg/ ml of semen. The effectiveness of such treatments was confirm...

a total of 183 coagulase negative staphylococcal infected quarters and 64 uninfected quarters were randomly allotted to 4 experimental groups: infected quarters that did not receive any treatment (positive control group; n = 60); infected quarters that received tylosin (n = 61) or cefquinome (n = 62) and also uninfected quarters that did not receive any treatment were considered as negative con...

Many antibiotics have been screened for inhibition of sporeforming bacteria during the last 10 years in this laboratory. The effect of some of these antibiotics on canned food spoilage bacteria has previously been described (Denny and Bohrer, 1959). Recently, two antibiotics which eventually may be of use in food processing have been through a preliminary screening in this laboratory. These ant...

Many antibiotics have been screened for inhibition of sporeforming bacteria during the last 10 years in this laboratory. The effect of some of these antibiotics on canned food spoilage bacteria has previously been described (Denny and Bohrer, 1959). Recently, two antibiotics which eventually may be of use in food processing have been through a preliminary screening in this laboratory. These ant...

Three series of semi-synthetic derivatives of tylosin-related macrolides were evaluated for utility in veterinary medicine. 23-Modified derivatives of 5-O-mycaminosyltylonolide (OMT) possessed potent activity in vitro against species of Pasteurella and Mycoplasma. An experimental infection in chicks caused by Pasteurella multocida was utilized to evaluate efficacy; several of these derivatives ...

The in vitro activities of aivlosin tylosin tiamulin, erythromycin, oxytetracycline, spectinomycin, lincomycin, lincomycin-spectinomycin (1:2) and enrofloxacin were determined against twenty-eight isolates of Mycoplasma gallisepticum and 4 isolates of Mycoplasma synoviae using microbroth dilution method. The isolates showed various susceptibilities to antimicrobial agents. Aivlosin, lincomycin-...

The potential impact of six antibiotics (chlortetracycline, tetracycline and tylosin; sulfamethoxazole, sulfamethazine and trimethoprim) on plant growth and soil quality was studied by using seed germination test on filter paper and plant growth test in soil, soil respiration and phosphatase activity tests. The phytotoxic effects varied between the antibiotics and between plant species (sweet o...