First introduced into clinical practice in 1969, glibenclamide (US adopted name, glyburide) is known best for its use in the treatment of diabetes mellitus type 2, where it is used to promote the release of insulin by blocking pancreatic KATP [sulfonylurea receptor 1 (Sur1)-Kir6.2] channels. During the last decade, glibenclamide has received renewed attention due to its pleiotropic protective e...

Background: Resistin and ghrelin are hormones that have roles in the glucose and lipid homeostasis and weight regulation. Human studies regarding resistin and ghrelin in diabetic patients are scarce, especially in the cases of normotensive and non-obese patients. This study was designed to illuminate some of the missing points.Methods: Eighty diabetic patients and eighty healthy individuals par...

diabetic retinopathy is a common complication of type ii diabetes mellitus and carries with it the threat of blindness. accurate information regarding the incidence of diabetic retinopathy and associated risk factors is important in the prevention of its development and of the visual impairment caused by this complication. this study was designed to determine the prevalence of diabetic retinopa...

Background and objectives: Diabetes is the most common metabolic disease in developing countries. Because the cause of many chronic diseases lies in the human's lifestyle, performing health promotion behaviors is the best way to maintain and improve the health. Hence, this study aimed to compare the health promoting behaviors based on the Pender model in at risk groups of type 2 diabetes in wom...

Objective: To study the efficacy and safety of glibenclamide/metformin combination as a treatment option for pregnant women with either gestational diabetes or type-2 diabetes mellitus compared to conventional insulin therapy. Methods: Eighty-four pregnant women with singleton pregnancies (65 women with gestational diabetes & 19 with type-2 diabetes mellitus) were included. They were randomly a...

We have studied the effects of first and second generation sulphonylureas on the release of insulin and neuropeptide tyrosine (NPY) from hamster insulinoma tumour (HIT T15) cells and isolated rat islets. In the presence of 5.5 mmol/l glucose all sulphonylureas stimulated insulin release from the HIT cells (P<0.01 ANOVA, n> or =4) but only glibenclamide (GLIB, 10 micromol/l) stimulated the relea...

AIMS Sulfonylureas may interfere with 'ischaemic preconditioning' and worsen the prognosis in diabetic patients with acute myocardial infarction. METHODS AND RESULTS Three hundred and fifty-seven non-diabetic patients admitted with acute myocardial infarction to one hospital over 6.5 years (72 deaths, in-hospital mortality 20.2%) were compared to 245 Type 2 diabetic patients categorized as ha...

background : pancreas as the insulin-producing gland is subjected to destruction and change in the diabetes-producing process. realtime sonography can assess the gland in 95% of cases and its accuracy in diagnosis of pancreatic disease matches that of ct-scan. the purpose of this study was to evaluate pancreatic diameter and echogenicity by sonography and to examine the correlation of these two...

Canarium schweinfurthii is a common medicinal plant used as food and medicine in communities of central Uganda. Local herbalists commonly it the management diabetes mellitus type 2 with limited information on its effectiveness.&nbsp; Study assessed hypoglycemic effect C. aqueous total crude leaf pulp extracts blood glucose levels Wistar albino rats. An experimental based laboratory-based study ...