There are only 10 contemporary, population-based studies of typhoid fever that evaluate disease incidence using blood culture for confirmation of cases. Reported incidence ranged from 13 to 976/100 000 persons per year. These studies are likely to have been done preferentially in high- incidence sites which makes generalization of data difficult. Only five of these studies reported mortality. O...

INTRODUCTION We describe a case of rare complication of typhoid fever in a seven-year-old child and review the literature with regard to other rare causes of bleeding per rectum. Dieulafoy's lesion is an uncommon but important cause of recurrent gastrointestinal bleeding. Dieulafoy's lesion located extragastrically is rare. We report a case of typhoid ulcer with Dieulafoy's lesion of the ileum ...

Current diagnostic tests for typhoid fever, the disease caused by Salmonella Typhi, are poor. We aimed to identify serodiagnostic signatures of typhoid fever by assessing microarray signals to 4,445 S. Typhi antigens in sera from 41 participants challenged with oral S. Typhi. We found broad, heterogeneous antibody responses with increasing IgM/IgA signals at diagnosis. In down-selected 250-anti...

Enteric fever which includes typhoid and paratyphoid fever is a systemic febrile illness caused by the bacterium Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A, B or C, respectively. Salmonella enterica serovar Typhi is found to be associated with over 90% cases of enteric fever. (Pandey et al, 2012) Typhoid fever is a noted cause of morbidity worldwide with an es...

OBJECTIVE The objective of this study is to evaluate the clinical profile and drug response in typhoid fever. METHODS This is a retrospective analysis of paediatric patients suffering from typhoid fever who were admitted at Kathmandu Medical College Teaching Hospital, Sinamangal during the period of two years and nine months. RESULTS Total numbers of 100 cases of typhoid were studied. Diagn...

Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans throughout history and continues to be a major public health concern. Unlike infections with most other Salmonellae, which result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease. Furthermore, in contrast to most Salmonellae, which can infect a broad range of hosts, S. Typh...

Surgical complications of typhoid fever usually involve the small gut, but infrequently typhoid fever also involves the gallbladder. Complications range from acalculous cholecystitis, gangrene to perforation. Here, we present a case of enteric fever with concomitant complication of multiple ileal perforations at its terminal part with acalculous cholecystistis with gangrenous gall bladder. The ...

BACKGROUND The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its reliability. METHODS We assessed the performance of the Widal tube agglutination...

BACKGROUND / AIMS Current diagnostic methods for typhoid fever have low sensitivity and specificity. This study aimed to develop an enzyme linked immunosorbent assay (ELISA) with greater sensitivity and specificity. METHODS The ELISA was developed and evaluated on patients with acute typhoid infection, febrile controls, and healthy controls. A sequential study on patients with culture confi...

BACKGROUND Typhoid fever is one of the most important infectious diseases transmitted by contaminated food and water. This study aimed at epidemiological features of disease during the last five decades, over the period from 1962-2011. METHODS A retrospective cross-sectional study was conducted using typhoid fever national surveillance data. RESULTS The highest incidence of typhoid fever wa...