The stable isotopic composition of insoluble, refractory elements such as titanium (Ti) or zirconium (Zr), which are modified by magmatic differentiation but, a priori, poorly affected weathering diagenesis, serve powerful potential proxies to reconstruct the compositional evolution continental crust. Here we present Zr compositions (?94/90ZrIPGP-Zr, per mille deviation 94Zr/90Zr from IPGP-Zr s...

Twenty-four composite samples of the fine-grained matrix glacial diamictites deposited from Mesoarchaean to Palaeozoic have been analysed for their silicon isotope composition and used establish, first time, long-term secular Si record compositional evolution upper continental crust (UCC). Diamictites with Archaean Palaeoproterozoic Nd model ages show greater heterogeneity than those younger (i...

Nature-Based Solutions (NBS) have been proven to effectively mitigate and solve resource depletion climate-related challenges in urban areas. The COST (Cooperation Science Technology) Action CA17133 entitled “Implementing nature-based solutions for building a resourceful circular city” has established seven circularity (UCC) that can be addressed with NBS. This paper presents the outcomes of fi...

Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline from the American College of Physicians. The ratio of forced expiratory volume in 1-second to forced vital capacity as a basis for establishing chronic obstructive pulmonary disease. Evaluating respiratory impairment in middle-aged persons using lambda-mu-sigma derived z-scores. Interpreting ...

Patients with refractory chronic cough (RCC) or unexplained (UCC) often have comorbid diseases associated and/or receive treatments for conditions presumed to be related their (RCC/UCC). The medical histories of patients RCC UCC enrolled in two phase 3, randomized, placebo-controlled studies the P2X3 receptor antagonist gefapixant were assessed. COUGH-1 (NCT03449134) and COUGH-2 (NCT03449147) i...

Objective To assess the relationship between emergency department (ED) and urgent care center (UCC) chief complaint data for gastrointestinal (GI) illness and reported norovirus (NV) outbreaks to develop an early warning tool for NV outbreak activity. The tool will provide an indicator of increasing NV outbreak activity in the community allowing for earlier public health action to mitigate NV o...

BACKGROUND Risks prediction models of 30-day all-cause hospital readmissions are multi-factorial. Severity of illness (SOI) and risk of mortality (ROM) categorized by All Patient Refined Diagnosis Related Groups (APR-DRG) seem to predict hospital readmission but lack large sample validation. Effects of risk reduction interventions including providing post-discharge outpatient visits remain unce...

Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. We have previously shown that FKA preferentially inhibits the growth of p53 defective bladder cancer cell lines. Here, we examined whether FKA could inhibit bladder cancer development and progression in vivo in the UPII-SV40T transgenic model that resembles human urothelial cell carcinoma (UCC) with defects in the p...

BACKGROUND Expansion of virtual health care-real-time video consultation with a physician via the Internet-will continue as use of mobile devices and patient demand for immediate, convenient access to care grow. OBJECTIVE The objective of the study is to analyze the care provided and the cost of virtual visits over a 3-week episode compared with in-person visits to retail health clinics (RHC)...

BACKGROUND Female smoking is perceived very negatively in East Asian countries such as South Korea, Japan, and China, as well as in Islamic countries. These countries' self-reported surveys (SRs) tend to produce results that underestimate the number of smokers, owing to the social desirability response bias. The present study seeks to assess South Korea, Europe, and the Americas, by comparing d...