BACKGROUND Mesenchymal stromal cells are employed in various different clinical settings in order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both the cell source and culture conditions. DESIGN AND METHODS We tested the ability of a 5% platelet lysate-supplemented medium to s...

Umbilical cord blood stem cell transplants are used to treat a variety of oncologic, genetic, hematologic, and immunodeficiency disorders. Physicians have an important role in educating, counseling, and offering umbilical cord blood donation and storage options to patients. Parents may donate their infant's cord blood to a public bank, pay to store it in a private bank, or have it discarded. Th...

Objectives: In multifetal pregnancies abnormalities within the umbilical cord occur much more frequently than in single pregnancy. This may be related to the presence of intra-uterine congestion, which is observed in the case of simultaneous development of a greater number of fetuses. These abnormalities may be responsible, at least in some cases, for high rate of perinatal morbidity and mortal...

Umbilical cord knots occur in 1-2% of all deliveries can lead to increase fetal death and asphyxia. A thorough examination is important discern abnormalities. Although there are not set guidelines for diagnosing managing umbilical knots; reporting with complications will aid decision making better future patient management. We describe one such case a primigravida who was found have an knot.

Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, t...

Although early exposure to environmental pollutants may have important toxicological consequences, the mechanisms of transplacental transfer of synthetic musks are still not well understood. The objective of the present study was to learn the musk contaminations in three matrices, including maternal blood, umbilical cord blood, and breast milk; and investigate their placental transfer mechanism...

1. It has been suggested that lowdose prenatal mercury exposure as measured by umbilical cord blood mercury concentrations of >29 nmol/L causes adverse long-term neurocognitive outcomes. 2. Of 608 children, 491 (81%) had umbilical cord blood mercury concentrations of >29 nmol/L. However, umbilical cord blood mercury concentrations were associated with only two out of 23 neurocognitive subtests....

Congenital hernia of umbilical cord is a less frequent entity in newborns and occasionally associated with other maladies. Herein, we report three unusual cases of hernia of umbilical cord. First case was associated with in-utero evisceration of entire small bowel through the presumably ruptured hernia of umbilical cord and other two cases had associated patent vitellointestinal duct (PVID). Al...