Coronavirus disease 2019 (COVID-19), the currently prevailing pandemic that has besieged whole world, is caused by a novel coronavirus, named as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, there was focus on disease, which and most predominant presentation. However, with increasing spread of infection consequent knowledge experience about it become apparent virus w...

Patients with chronic kidney disease (CKD) are at high risk for developing critical illness and for admission to intensive care units (ICU). 'Critically ill CKD patients' frequently develop an acute worsening of renal function (i.e. acute-on-chronic, AoC) that contributes to long-term kidney dysfunction, potentially leading to end-stage kidney disease (ESKD). An integrated multidisciplinary eff...

Patients with polycystic kidney disease (PKD) have a high risk of developing renal cell carcinoma (RCC). SET domain–containing 2(SETD2) is the only molecule known to regulate lysine trimethylation (H3K3me3) histone H3 in human tissue, and SETD2 identified as tumor suppressor ccRCC. Although there are some studies revealing mechanism about PKD ccRCC, underlying remains largely reported. We colle...

Summary Monoclonal gammopathy of renal significance (MGRS) encompasses a group kidney disorders in which monoclonal immunoglobulin secreted by B cell or plasma clone causes damage, without meeting hematological criteria for malignancy. The underlying disorder patients with MGRS is generally consistent undetermined (MGUS). Because the wide spectrum MGRS-associated diseases, defined through locat...

Acute kidney injury predisposes patients to the development of both chronic kidney disease and end-stage renal failure, but the molecular details underlying this important clinical association remain obscure. We report that kidney injury molecule-1 (KIM-1), an epithelial phosphatidylserine receptor expressed transiently after acute injury and chronically in fibrotic renal disease, promotes kidn...

Because chronic kidney disease is a growing health concern, family physicians must be equipped to care for this unique patient population. Diabetes mellitus and hypertension, which are commonly addressed in the office setting, are the largest contributors to chronic kidney disease; therefore, these risk factors should be tightly controlled and these patients should be screened closely for signs...

Citation: Das F. Identify the Underlying Mechanisms Driving the Pathogenesis of Diabetic Nephropathy. Adv kidney Dis Treat. 2016, 1:1. My research focuses on understanding the cellular and molecular mechanisms of different types of kidney disease and to identify the signalling pathways that regulate kidney disease. Understanding the components in these signalling pathways and their mechanisms o...

Acute kidney injury (AKI) is the second prevalent organ damage among COVID-19 infected individuals, which mainly affects those with critical diseases or underlying disorders. Emerging data have suggested that AKI associated adverse outcomes, severe disease, and high mortality. However, true nature pathophysiology of COVID-19-associated injury, its effect on patients transplant recipients, still...

ETIOLOGY The cause of CKD is difficult to determine when diagnosed in later stages of disease. Damage can occur to any part of the nephron, including the glomerulus, tubule, interstitial tissue or vasculature, which can result in irreversible damage and loss of function of the nephron. The more common causes of CKD in dogs and cats include incomplete recovery from an acute renal injury (toxic, ...