BACKGROUND The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly understood. METHODS From March, 2004 to January, 2007, 119 women were prospectively included: 32 oocyte donors, 31 patients with UI, 26 with IF and 30 with RSA. The IF and RSA groups presented normal preim...

Recurrent spontaneous miscarriage (RSM), defined as ≥2 clinically detectable pregnancy losses before 20 weeks of gestation with the same partner. Many studies have been suggested abnormal natural killer (NK) cell activity can be a high chance division linked with RSM. Aberrant expression of angiogenic cytokines during implantation window in women with RSA is one of the key factors that adversel...

Sperm morphology displays a potential impact on sperm function and may ultimately impact reproductive function. Current studies have investigated the correlation between sperm morphology with unexplained recurrent spontaneous abortion (RSA) but have shown inconsistent results. Hence, we systematically searched MEDLINE, EMBASE, CNKI databases, as well as the Cochrane Library for studies that exa...

The role of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C, methioninesynthase reductase (MTRR) A66G was unclear in repeated spontaneous abortion. To provide experimental basis for etiological diagnosis and treatment of recurrent spontaneous abortion, we selected 197 patients with recurrent spontaneous abortion and 116 normal women, extracting the oral mucosal epithelial cells and de...

abstract background a vast variety of factors may cause recurrent pregnancy loss. blood group incompatibility of parents could cause abortion. the examination of couples or twins, blood groups showed that the blood group incompatibility can affect adversely the outcome of pregnancy. couples with blood group incompatibility are more involved in spontaneous miscarriage. antigenes in two different...

BACKGROUND Environmental and endocrine factors have been implicated in the aetiology of recurrent abortion, with poorly understood roles. Luteal phase insufficiency marked with insufficient progesterone secretion has been reported. OBJECTIVE To define the involvement of progesterone, trace metals, and Vitamin E in pregnant women with history of recurrent spontaneous abortion. METHODS Conven...

CONTEXT Bacterial vaginosis (BV) is related to the increased risk of miscarriage, preterm labor, and postpartum endometritis. AIMS The aim of this study was to evaluate the association between BV and the history of spontaneous abortion and recurrent pregnancy losses. We also examined periods of gestation, including the first and second trimester miscarriages. MATERIALS AND METHODS The study...

Since half of the genes are inherited from paternal side, maternal immune system has to tolerate presence foreign antigens. Regulatory T cells facilitate development and maintenance peripheral tissue tolerance fetus during pregnancy. Reduction in regulatory is associated with complications pregnancy, including spontaneous abortion. Recent studies mouse models have shown that adoptive transfer T...

An increased frequency of mitoses with centromere separation affecting all chromosomes was found in lymphocyte cultures of couples with recurrent spontaneous abortions. This anomaly was recorded in six individuals out of seventy couples (one hundred and forty individuals) with recurrent miscarriages. The abnormal behaviour of centromeres may predispose the individual to cell division errors, th...