Tubulointerstitial injuries are crucial histological alterations that predict the deterioration of renal function in chronic kidney disease. ONO-1301, a novel sustained-release prostacyclin analog, accompanied by thromboxane synthase activity, exerts therapeutic effects on experimental pulmonary hypertension, lung fibrosis, cardiomyopathy, and myocardial ischemia, partly associated with the ind...

Obstructive nephropathy is a term describing the damage to the renal parenchyma that results from the obstruction to the flow of urine anywhere along the urinary system. Long term obstruction causes chronic renal disease. Obstruction coexisting with infection and impaired renal function, when complicated by elevated temperature and leukocytosis that can lead to septic shock, are an absolute ind...

Renal sonographic findings can now be implicated for prediction of changes in Glomerular filtration rate, and estimation of the degree of renal dysfunction in pets. This was successfully determined during a 20-day chronic unilateral ureteral obstruction in experimental dogs. GFR was quantitatively measured following a single intravenous bolus of inulin. The total clearance of the marker was cal...

Estrogen may help to preserve renal function in chronic kidney disease. This study examined whether estrogen administration or deprivation affected the split renal function in rats subjected to chronic unilateral ureteral obstruction (UUO). Fifteen adult female Sprague-Dawley rats were randomly divided into three groups. Low- and high-estrogen groups were modeled by female castration or estroge...

Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using antisense oligonucleotides (ASOs) targeting CD40, would be beneficial in mouse models of glomerular injury and unilateral ureter obstruction. Admi...

Sir, A 5-mo-old male infant was brought with history of cough, cold and fever of 2 d duration and excessive cry for 3 h prior to admission. There were no similar complaints in the past. On examination, the baby was febrile, fussy and crying excessively. His vitals were normal. Examination was unremarkable except for a palpable liver 2 cm below right costal margin and a distended urinary bladder...

BACKGROUND Renal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor γ (PPARγ) agonists have a protective effect on diabetic nephropathy, much less is known about their direct effects in renal fibrosis. This study aimed to investigate possible beneficial effects of lob...

Oxidized low-density lipoproteins (oxLDL) and their scavenger receptor (SR) binding partners play a central role in atherosclerosis and by analogy may play a role in chronic kidney disease pathogenesis. The present study was designed to investigate in C57BL/6 mice the effects of hypercholesterolemia on renal injury severity and oxLDL generation after unilateral ureteral obstruction (UUO). The e...