does not appear to accompany muscle unloading since neither AP-1 nor NFAT activity is activated 5. JNK activity and TNF levels are unchanged in unloaded muscles further supporting a lack of an inflammatory response. Lastly, there is no evidence of complement activation in unloaded muscles 8. Results from immunoblotting of nuclear extracts and gel supershift assays suggested that the Rel protein...

The present investigation presents a stochastic model for a flexible manufacturing system consisting of flexible machine, loading/unloading robot and an automated pallethandling device. We consider unreliable flexible manufacturing cell (FMC) wherein machine and robot operate under individual as well as common cause random failures. The pallethandling system is completely reliable. The pallet o...

In this paper efficient in time methods for support decision-making processes in small container terminal operated by reachstackers are proposed. Two main problems are considered: first, minimization the number of loading/unloading operations between container trains and bays, second, minimization the number of re-handing operations within container bays. in Gliwice, Poland to model the problem...

Animals rely on an adaptive coordination of legs during walking. However, which specific mechanisms underlie coordination during natural locomotion remains largely unknown. One hypothesis is that legs can be coordinated mechanically based on a transfer of body load from one leg to another. To test this hypothesis, we simultaneously recorded leg kinematics, ground reaction forces and muscle acti...

The sliding clamp PCNA is a crucial component of the DNA replication machinery. Timely PCNA loading and unloading are central for genome integrity and must be strictly coordinated with other DNA processing steps during replication. Here, we show that the S. cerevisiae Elg1 replication factor C-like complex (Elg1-RLC) unloads PCNA genome-wide following Okazaki fragment ligation. In the absence o...

OBJECTIVES This study tested the hypothesis that first reducing myocardial work by unloading the left ventricle (LV) with a novel intracorporeal axial flow catheter while delaying coronary reperfusion activates a myocardial protection program and reduces infarct size. BACKGROUND Ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary myocardial reperfusion remain...

Mueller, Patrick J., Margaret J. Sullivan, Regina R. Grindstaff, J. Thomas Cunningham, and Eileen M. Hasser. Regulation of plasma vasopressin and renin activity in conscious hindlimb-unloaded rats. Am J Physiol Regul Integr Comp Physiol 291: R46–R52, 2006. First published February 9, 2006; doi:10.1152/ajpregu.00622.2005.—Cardiovascular deconditioning occurs in astronauts after spaceflight or in...

In the process of automatic container terminal loading and unloading, three-dimensional attitude affects security unloading operations, so positioning is very important. this paper, a visual non-contact measurement method used to realize real-time orientation container. First, corner coarsely positioned by small-scale deep learning network. Secondly, precise position keyhole obtained secondary ...