unrelated donors

Approximately 1 in 20 unrelated donors are asked to make a second donation of hematopoietic progenitor cells, the majority for the same patient. Anthony Nolan undertook a study of subsequent hematopoietic progenitor cell donations made by its donors from 2005 to 2011, with the aims of predicting those donors more likely to be called for a second donation, assessing rates of serious adverse reac...

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the association between human leukocyte antigen class ii dr3–dq2 haplotype and type 1 diabetes in children of the east azerbaijan state of iran

Journal: :iranian red crescent medical journal 0

sima mansoori derakhshan immunology research center, tabriz university of medical sciences, tabriz, ir iran; department of medical genetic, faculty of medicine, tabriz university of medical sciences, tabriz, ir iran fatemeh zeinali sehrig department of biological science, ahar branch, islamic azad university, ahar, ir iran nasrin sohrabi immunology research center, tabriz university of medical sciences, tabriz, ir iran; department of medical genetic, faculty of medicine, tabriz university of medical sciences, tabriz, ir iran siamak shiva department of pediatrics, faculty of medicine, tabriz university of medical sciences, tabriz, ir iran behzad baradaran immunology research center, tabriz university of medical sciences, tabriz, ir iran mahmoud shekari khaniani immunology research center, tabriz university of medical sciences, tabriz, ir iran; department of medical genetic, faculty of medicine, tabriz university of medical sciences, tabriz, ir iran; department of medical genetic, faculty of medicine, tabriz university of medical sciences, tabriz, ir iran. tel: +98-4113371587, fax: +98-4113371587

conclusions our investigation demonstrated that there is a highly significant association between the studied alleles and t1d. it can be construed that haplotype hla-dr3-dq2 has a very modest effect with respect to the risk of t1d. patients and methods this study was a case-control study. the number of samples was determined using the cochran formula. eighty unrelated t1d patients, including 42...

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unrelated cord blood transplantation in severe combined immuno¬deficiency (scid) patients, the first report in iran

Journal: :international journal of hematology-oncology and stem cell research 0

a ghavamzadeh hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences a moosavi hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences a hedayatiasl hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences k alimoghadam hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences b bahar hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences m moghimi hematology-oncology and bone marrow transplantation research center, tehran university of medical sciences

severe combined immunodeficiency is a true pediatric emergency; children with scid were the first patients with immunodeficiencies to be successfully transplanted with unrelated and t-cell-depleted, haploidentical bone marrow. the pattern of inheritance of scid is x-linked and autosomal recessive (ada def, jak3, rag1, rag2, il 7rα). in this case report, we describe a one-year-old boy with b+t- ...

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NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies.

Journal: :Haematologica 2009

J Luis Espinoza Akiyoshi Takami Makoto Onizuka Hiroshi Sao Hideki Akiyama Koichi Miyamura Shinichiro Okamoto Masami Inoue Yoshinobu Kanda Shigeki Ohtake Takahiro Fukuda Yasuo Morishima Yoshihisa Kodera Shinji Nakao

BACKGROUND NKG2D, an activating and co-stimulatory receptor expressed on natural killer cells and T cells, plays pivotal roles in immunity to microbial infections as well as in cancer immunosurveillance. This study examined the impact of donor and recipient polymorphisms in the NKG2D gene on the clinical outcomes of patients undergoing allogeneic T-cell-replete myeloablative bone marrow transpl...

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Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation

2015

Rosalie A. Poldervaart Mirjam Laging Tessa Royaards Judith A. Kal-van Gestel Madelon van Agteren Marry de Klerk Willij Zuidema Michiel G. H. Betjes Joke I. Roodnat

Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been performed. In conventional and ABO-incompatible transplantation the willing donor becomes an actual don...

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