نتایج جستجو برای: uracil derivatives
تعداد نتایج: 109669 فیلتر نتایج به سال:
4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (2-thiouracil) is reacted with a series of diazotized aromatic amines to give compounds On the other hand compound is -methylated by methyl iodide giving 4-oxo-2-methylthioxo 1,2,3,4tetrahydropyrimidine which inturn is reacted with a series of diazotized aromatic amines giving arylazo derivatives of the type . In another reaction compound is hydrolyse...
The kinetics o f inhibition o f photosystem II electron transfer by different diuron-like herbi cides (ureas, triazines, triazinones. biscarbam ates, uraciles) were studied, mainly by chloro phyll fluorescence measurem ents. Uracil derivatives and cyanazine, a particu lar triazine, were the slowest acting com pounds. The half-times o f action were strongly tem perature-dependent and were o f ...
(Carbo)nucleoside derivatives constitute an important class of pharmaceuticals, yet there are only few convergent methods to access new analogues. Here, we report the first synthesis of thymine-, uracil-, and 5-fluorouracil-substituted diester donor-acceptor cyclopropanes and their use in the indium- and tin-catalyzed [3+2] annulations with aldehydes, ketones, and enol ethers. The obtained dies...
Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase. Lack of the major uracil-DNA glycosylase UNG gene from the fruit fly genome and dUTPase from fruit fly larvae prompted the hypotheses that i) uracil may accumulate in Drosophila genomic DNA where it may be well tolerated, an...
Bacteriophage T5 induces a deoxyuridine B’-triphosphate nucleotidohydrolase (dUTPase) activity during infection of Escherichiu coli. A T5 mutant (T5 dut) unable to induce this dUTPase activity has been isolated. Although this mutant is viable, the E. coli dUTPase activity is not sufficiently active to exclude uracil from the progeny DNA and about 3% of the thymine is replaced by uracil. When th...
Various octadeoxynucleotides containing uracil at different positions were synthesized and submitted to the action of Escherichia coli and Micrococcus luteus uracil-DNA glycosylases. A uracil residue situated at the 5'-end was excised by the M.luteus enzyme but not by the E.coli one. Uracil residues located at the ultimate and penultimate positions at the 3'-end were not cleaved by either enzym...
Uracil DNA glycosylases (UDGs) excise uracil fromDNA and initiate the base (uracil) excision repair pathway. Ung, a highly conserved protein, is the only UDG characterized so far in mycobacteria. Here, we show that Rv1259 fromMycobacterium tuberculosis codes for a doublestranded DNA (dsDNA) specific UDG (MtuUdgB). MtuUdgB is thermo-tolerant, contains Fe–S cluster and, in addition to uracil, it ...
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