نتایج جستجو برای: urate deposition
تعداد نتایج: 96523 فیلتر نتایج به سال:
INTRODUCTION There is increasing evidence that both hyperuricemia and gout increase the risk of cardiovascular morbidity and mortality. Whether urate crystal precipitation confers a particular risk above what is already inherent in having hyperuricemia is not well established. We conducted this cohort study to establish whether the presence of monosodium urate crystal precipitation per se is as...
BACKGROUND Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucos...
Gout is a heterogeneous group of diseases resulting from monosodium urate (MSU) crystal deposition in tissues or from supersaturation of uric acid in extracellular fluids. Clinical manifestations include 1) Recurrent attacks of articular and periarticular inflammation, also called gouty arthritis; 2) Accumulation of articular, osseous, soft tissue, and cartilaginous crystalline deposits, called...
0886-1714/99 5.00 © 1999 Int. Union Physiol. Sci./Am.Physiol. Soc. 80 The renal urate handling in humans has been explained for many years by a “four-component model.” The purpose of this review is to reevaluate the validity of the theory behind this hypothetical model in the light of the transport mechanisms that were characterized recently in the apical membrane (brush-border membrane; BBM) o...
Gout is a metabolic disease characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals in the joints and soft tissues, consisting of a self-limited acute phase characterized by recurrent attacks of synovitis and a chronic phase in which inflammatory and structural changes of the joints and periarticular tissues may lead to persistent symptoms. Acute gout is characteriz...
BACKGROUND AND PURPOSE Serum urate concentration is associated with cardiovascular disease, and hyperuricemia predicts first-ever stroke. We explored the association of admission urate level with mortality, placement, and risk of further vascular events after acute stroke. METHODS In patients with ischemic stroke or primary intracranial hemorrhage, we determined the association of urate level...
The classical description of Gout (za lrobayplKa-f7robaypa 'the foot-pain'-Aristotle, 350 BC; Hippocrates, 430 BC) suggests that the earliest references were to the characteristic crystal synovitis of the first metatarsophalangeal joint. Antoni van Leuwenhoek published a beautiful drawing of urate crystals from a tophus in 1679. Since that time the term 'gout' has been applied to an increasingl...
BACKGROUND Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body. The purpose of this study was to characterize the incidence and diagnostic features of visceral gout found at necropsy in two patients. CASE PRESENTATION The authors present an unusual report of untreated gout leading to ma...
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