Abstract Background and Aims Chronic kidney disease associated pruritus (CKD-aP) has been recognized for over a century. The actual proposed off-label therapeutic option is gabapentin, that showed relevant efficacy in some small trial. Recently difelikefalin (DFK), k-opioid receptor agonist, the first FDA EMA approved drug CKD-aP treatment. We report three treated patients suffering gabapentin-...

Copyright © 2016 G. Litscher and P.-J. Rong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This special issue includes six interesting manuscripts. Auric-ular acupuncture is a method which has been successfully used in various f...