Cerebellar basket cells form highly specialized inhibitory synaptic contacts with Purkinje cells, namely the pericellular basket and pinceau nerve terminal structures, wrapping around the Purkinje cell somatic and axon hillock regions. These inhibitory synaptic contacts are ideally located to control the ultimate output of the cerebellar cortex. Previous immunohistochemical studies have shown t...

In eukaryotes, mRNA export involves many evolutionarily conserved factors that carry the nascent transcript to the nuclear pore complex (NPC). The THO/TREX complex couples transcription to mRNA export and recruits the mRNA export receptor NXF1 for the transport of messenger ribonucleoprotein particles (mRNP) to the NPC. The transcription and export complex 2 (TREX-2) was suggested to interact w...

The market basket is defined as an itemset bought together by a customer on a single visit to a store. The market basket analysis is a powerful tool for the implementation of cross-selling strategies. Especially in retailing it is essential to discover large baskets, since it deals with thousands of items. Although some algorithms can find large itemsets, they can be inefficient in terms of com...

I Is fitting that the inaugural issue of the Journal ofthe American Society ofNephrology highlights the 1990 Long Range Plan of the National Kidney and Urologic Diseases Advisory Board. The release of this historic report in March 1 990 signalled the beginning of a critical period for the future of nephrology. Achievement of the major recommendations outlined In this long-range plan would subst...

Somatic inhibition, which is critical for determining the spike output of principal cells, is mediated by two physiologically distinct classes of GABAergic interneurons called basket cells. In the hippocampus, despite both targeting the somatic membrane of CA1 pyramidal cells, these two classes of basket cells are active at different times. Differential modulation of these two types of basket c...