ed Plant Hybrid Dispatcher Qualitative Control Plan Plan Compiler Control actions Plant state Plant Model 11 A V ehic le 1 [100, 200] 21 A V ehic le 2 22 A [70 , 90 ] [50 , 100] [0 , 200] Disturbance displaces trajectory 2200 max 2000 min 1 1 = = xg xg 11 A V eh icle 1 [100, 200 ] 21 A V eh icle 2 22 A [70 , 90] [50, 100] 1800 max 1500 min 2 2 = = xg xg

Cannabis has potential therapeutic use but tetrahydrocannabinol (THC), its main psychoactive component, appears as a risk factor for ischemic stroke in young adults. We therefore evaluate the effects of THC on brain mitochondrial function and oxidative stress, key factors involved in stroke. Maximal oxidative capacities V max (complexes I, III, and IV activities), V succ (complexes II, III, and...

We explored the properties of a catenary model that includes the basolateral (B), apical (A), and cellular compartments via simulations under linear and nonlinear conditions to understand the asymmetric observations arising from transporters, enzymes, and permeability in Caco-2 cells. The efflux ratio (EfR; P(app,B-->A)/P(app,A-->B)), obtained from the effective permeability from the A-->B and ...

This thesis deals with approximation algorithms for problems in mathematical programming, combinatorial optimization, and their applications. We first study the Convex Min-Max Resource-Sharing problem (the Packing problem as the linear case) with M nonnegative convex constraints on a convex set B, which is a class of convex programming. In general block solvers are required for solving the prob...

Strategies for the prediction of in vivo drug clearance from in vitro drug metabolite kinetic data are well established for the rat. In this animal species, metabolism rate-substrate concentration relationships can commonly be described by the classic hyperbola consistent with the Michaelis-Menten model and simple scaling of the parameter intrinsic clearance (CL(int) - the ratio of V(max) to K(...

Given a complete graph G = (V,E) with a metric cost function c : E → R and two vertex subsets R ⊂ V and R ⊆ R, a partial-terminal Steiner tree is a Steiner tree which contains all the vertices in R such that all the vertices in R are leaves. The partial-terminal Steiner tree problem (PTSTP) is to find a partial-terminal Steiner tree with the minimum cost. The problem has been shown to be NP-har...

Great uncertainty exists in the global exchange of carbon between the atmosphere and the terrestrial biosphere. An important source of this uncertainty lies in the dependency of photosynthesis on the maximum rate of carboxylation (V cmax) and the maximum rate of electron transport (J max). Understanding and making accurate prediction of C fluxes thus requires accurate characterization of these ...

The electrophysiological properties of embryonic chick hearts (ventricles) change during development; the largest changes occur between days 2 and 8. Resting potential (E(m)) and peak overshoot potential (+E(max)) increase, respectively, from -35 mv and +11 mv at day 2 to -70 mv and +28 mv at days 12-21. Action potential duration does not change significantly. Maximum rate of rise of the action...

Let G = (V, E) be a connected graph with a weight function w : V → Z+ and let q ≥ 2 be a positive integer. For X ⊆ V , let w(X) denote the sum of the weights of the vertices in X . We consider the following problem on G: find a q-partition P = (V1, V2, . . . , Vq) of V such that G[Vi] is connected (1 ≤ i ≤ q) and P maximizes min{w(Vi) : 1 ≤ i ≤ q}. This problem is called Max Balanced Connected ...

There are three isoforms of class V myosin in mammals. While myosin Va has been studied well, little is known about the function of other myosin V isoforms (Vb and Vc) at a molecular level. Here we report the mechanoenzymatic function of human myosin Vb (HuM5B) for the first time. Electron microscopic observation showed that HuM5B has a double-headed structure with a long neck like myosin Va. V...