Two heterometallic deca-vanadate(V) compounds, bis-(tetra-methyl-ammonium) deca-aquadi-μ4-oxido-tetra-μ3-oxido-hexa-deca-μ2-oxido-hexa-oxidodimang-anese(II)-deca-vanadate(V) penta-hydrate, (Me4N)2[V10O28{Mn(H2O)5}2]·5H2O, A, and bis-{[tris-(hy-droxy-meth-yl)meth-yl]ammonium} deca-aquadi-μ4-oxido-tetra-μ3-oxido-hexa-deca-μ2-oxido-hexa-oxidodimanganese(II)deca-vanadate(V) dihydrate, [NH3C(CH2OH)3...

The effect of vanadate on proteoglycan synthesis by cultured rabbit costal chondrocytes was examined. Rabbit chondrocytes were seeded at low densities and grown to confluency in medium supplemented with 10% fetal bovine serum, and then the serum concentration was reduced to 0.3%. At the low serum concentration, chondrocytes adopted a fibroblastic morphology. Addition of 4 microM vanadate to the...

Human platelet activation is associated with, and regulated by, the phosphorylation of a number of proteins. Recently, attention has been focused on tyrosine phosphorylation of proteins and their function in platelet activation. Here vanadate, an inhibitor of tyrosine phosphohydrolase, was used to examine the role that tyrosine phosphorylation plays in platelet activation. Vanadate (7.5 to 100 ...

Hypotonic exposure provokes the mobilization of arachidonic acid, production of ROS, and a transient increase in taurine release in Ehrlich Lettre cells. The taurine release is potentiated by H(2)O(2) and the tyrosine phosphatase inhibitor vanadate and reduced by the phospholipase A(2) (PLA(2)) inhibitors bromoenol lactone (BEL) and manoalide, the 5-lipoxygenase (5-LO) inhibitor ETH-615139, the...

We have shown that myosin light chain phosphorylation inhibits fiber shortening velocity at high temperatures, 30 degrees C, in the presence of the phosphate analog vanadate. Vanadate inhibits tension by reversing the transition to force-generating states, thus mimicking a prepower stroke state. We have previously shown that at low temperatures vanadate also inhibits velocity, but at high tempe...

Abstract Organic esters of phosphoric acid and other organophosphorous compounds are enzymatically hydrolyzed during wastewater treatment by microbial phosphoesterases, especially phosphomonoesterase (phosphatase). For physiological reasons, the enzyme is inhibited its main inorganic reaction product, ortho-phosphate. It known that oxyanions transition metals, resembling molecular topology orth...

Quasi-binary phosphate-vanadate glasses have been studied by both IR spectroscopy and a novel method of molecular dynamics with non-constant force field. This is used for the self-assembly structural models glasses. The obtained glass network structure are analyzed quantitatively using element distribution number R–O–R bonds (R phosphorous or vanadium) 4-, 6-, 8-membered cycles. bends on concen...

Friend murine erythroleukemia cells underwent apparently normal erythropoiesis when treated with dimethyl sulfoxide. One of the earliest events associated with this induction was a decrease in ouabain sensitive 86Rb+ uptake, an assay of the plasma membrane Na, K(ATPase). Ammonium vanadate (10/~M) blocked differentiation of these cells without affecting cell viability. Vanadium was taken up by F...

For the condensation of anions such as phosphate and ADP to form ATP and water, nature employs sophisticated supramolecular systems to overcome coulomb repulsion and activation barriers. For an attempt to create a simple, analogous chemical system, the dimerization of vanadate is probably the simplest model. We have investigated Zn-benzylcyclene which favors the dimerization thermodynamically a...