BACKGROUND Although pheochromocytomas are believed to account for fewer than 0.3% of all cases of hypertension, aggressive diagnostic and surgical intervention is recommended whenever a pheochromocytoma is suspected because uncontrolled catecholamine release from the tumors can lead to catastrophic consequences. Many biochemical diagnostic and imaging localization tests exist for detecting pheo...

Bond, J.V. (1975). Archives of Disease in Childhood, 50, 691. Clinical significance of catecholamine excretion levels in diagnosis and treatment of neuroblastoma. The pattern of urinary excretion of vanillylmandelic acid (VMA) was studied in 50 children with neuroblastoma. There were 10 disease-free survivors, and 4 children who survive for 3 or more years with residual nonmetastatic disease, 3...

A 15 month old male child presented to the department of Paediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India, in February 2014, with complaints of fever, progressive pallor, abdominal mass and visible skull swelling (Fig. 1). X-ray of the skull (Fig. 2) raised the possibility of metastatic neuroblastoma. Other differential diagnoses included fibrous dysplasia, Ewing’s...

PURPOSE We aimed to retrospectively evaluate the risk factors for hypertensive attack during adrenalectomy in patients with pheochromocytoma. Despite the development of newer surgical and anesthetic techniques for the management of pheochromocytoma, intraoperative hypertensive attack continues to present a challenge. MATERIALS AND METHODS Data from 53 patients diagnosed with pheochromocytoma ...

Pheochromocytomas are rare tumours originating from the chromaffin tissue. The clinical manifestations are variable and are not specific; as a result, pheochromocytomas often imitate other diseases. The diagnosis is usually established by biochemical studies, i.e., the measurement of catecholamines or their metabolites in urine or plasma, followed by radiographic and scintigraphic studies for l...

Malignant pheochromocytomas respond to chemotherapy with a reduction in tumor size and catecholamine secretion. We investigated the usefulness of molecular imaging with meta-iodobenzylguanidine (MIBG) for evaluating the effects of chemotherapy in patients with malignant pheochromocytoma. Six patients were studied before and after 6 ± 4 months of combination chemotherapy with cyclophosphamide, v...

BACKGROUND Adrenal corticomedullary mixed tumours are very rare. Its mechanism is rarely reported. Here we report the first case of a corticomedullary mixed tumour resembling a "small adrenal gland" with distinct arrangement of the cortical and medullary layers. We further hypothesize regarding the tumorigenic mechanism of this tumour. CASE PRESENTATION A 58-year man had been diagnosed with d...

A case study is presented of a 34-year-old female who was diagnosed with a markedly hydronephrotic right kidney. The patient underwent a cystoscopy and a right nephrectomy during which a pheochromocytoma was suspected and subsequently confirmed by postoperative histologic examination. No laboratory analysis for urinary metanephrines or vanillylmandelic acid was carried out. Major problems assoc...

CASE REPORT A 26-year-old man presented with recurrent painless total gross hematuria with amorphous clots for the past 6 months, a single episode of syncopal attack 5 days prior to presentation, and occasional postmicturition headaches. He was previously diagnosed with a bladder calculus. Cystoscopy revealed an oval wide-based solid mass involving the right posterolateral bladder wall. Tissue ...

The aim of the study was to assess the possible correlation between catecholamine and cortisol levels and changes in cerebral hemodynamics in patients with chronic posttraumatic stress disorder (PTSD). The study included 50 patients with chronic PTSD first ever hospitalized for psychiatric treatment and 50 healthy control subjects. All study subjects were aged 30-50. In PTSD patients, 24-h urin...