BACKGROUND Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals and sub-populations of individuals with attention deficit hyperactivity disorder (ADHD). We investigated the effects of MPH on brain plasticity vi...

Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). Because of its controversial useful effects, the combination of MP and other pharmacological agents to enhance neuroprotective effects is desirable. Magnesium sulfate (MgSO4) has been shown to have neuroprotective and antihyperalgesic effects. In the present study, we soug...

Abstract OBJECTIVES Chemotherapy-related cognitive impairment (CRCI) and chemotherapy-induced peripheral neuropathy (CIPN) are neurological complications of cancer treatment. Cisplatin is used to treat ovarian malignancies, over 70% women experience CRCI/CIPN during after platinum-based chemoTx. However, 30% non-CNS patients prior To examine the contribution itself additional with chemoTx, we a...

Objective: Estrogen deficit following menopause results in cognitive behaviors impairment. Severity of these impairments in menopause women suffer with cerebral hypo perfusion/ischemia (HI) cause the brain damage and neuronal death. This study aimed to evaluate the effects of pomegranate seed extract (PGSE) on avoidance memories after permanent bilateral common carotid arteries occlusion (2CCAO...

BACKGROUND Scorpion sting is a public health problem in Khuzestan, South-West Iran. The aims of the current study were to monitor the hospitalized children, due to scorpion sting, and releasing more clinical and epidemiologic data related to scorpionism in this Province. METHODS In this retrospective study, the data of scorpion sting victims, among the hospitalized children in Abuzar Children...

An important substrate of atrial fibrillation (AF) is fibrosis, and a higher burden fibrosis correlates with worse prognosis therapy resistance. Currently, no therapies exist that target fibrosis. JK07 long-acting neuregulin-fusion protein activates the ERBB4 receptor, which mitigates ventricular in models heart failure. To test ability to reduce AF inducibility minipig model deoxycorticosteron...

Abstract OBJECTIVES Chemotherapy-related cognitive impairment (CRCI) and chemotherapy-induced peripheral neuropathy (CIPN) are neurological sequelae of platinum-based chemotherapy. To examine the contribution cancer itself additional with chemotherapy, we used ID8 syngeneic ovarian mouse model assessed cognition hyperalgesia +/- cisplatin treatment. We examined effect p38 c-JUN N-terminal kinas...

Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut a major source ammonia production that contributes to hyperammonemia CLD and HE remains primary therapeutic target for lowering hyperammonemia. As an ammonia-lowering strategy, Escherichia coli Nissle 1917 bacterium was genetically modified consume convert arginin...

The development of cantilever-based piezoelectric vibrational energy harvesters (VEHs) is reaching a critical transition into commercial applications but being held back because the lack understanding regarding fatigue these systems. Identifying possible phenomena for VEH gives good basis knowledge creation numerical models. an electromechanical model carried out to capture property variations ...

Loss of muscle and bone mass with age are significant contributors to falls and fractures among the elderly. Myostatin deficiency is associated with increased muscle mass in mice, dogs, cows, sheep and humans, and mice lacking myostatin have been observed to show increased bone density in the limb, spine, and jaw. Transgenic overexpression of myostatin propeptide, which binds to and inhibits th...