Versican is highly expressed during the early stages of tissuedevelopment and its expression is elevated duringwound repair and tumor growth. There is little literature on the potential role of breast cancer stem cells on the cellular– extracellular matrix interactions involving versican. An anti-versican short hairpin RNA (shRNA) was used to observe the effect of reduction of versican on breas...

There is increasing evidence to suggest that extracellular matrix (ECM) components play an active role in tumor progression and are an important determinant for the growth and progression of solid tumors. Tumor cells interfere with the normal programming of ECM biosynthesis and can extensively modify the structure and composition of the matrix. In ovarian cancer alterations in the extracellular...

Background Components of the extracellular matrix have been studied in the attempt to elucidate the mechanisms involved with biological behavior of tumours. The presence of the proteoglycan versican has been strongly associated to cancer development and progression, however its relationship with invasion and tumoral progression has been little studied in veterinary medicine. Carcinomas in benig...

BACKGROUND Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incubated with conditioned media (CMs) from human breast cancer adipose tissue explants (hATT) or normal breast adipose tissue explants (hATN); 2) in hATN-CMs vs hATT-CMs; 3) in the...

Cancer‑associated fibroblasts (CAFs) in the tumor microenvironment play an essential role progression of esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate expression CAF‑related molecules, versican, periostin and lumican, cancer stroma, provide prognostic stratification for patients with ESCC after surgery. A total 106 who underwent curative esophagectomy without...

BACKGROUND The pathogenesis of crescentic glomerulonephritis (CGN) involves cellular migration and proliferation in the urinary space, frequently followed by fibrous organization. Extracellular matrix proteoglycans (PGs) may regulate these events via effects on cellular migration, interactions with growth factors, including transforming growth factor-beta (TGF-beta), and control of collagen fib...

Oligodendrocyte myelin glycoprotein (OMgp) is expressed by both neurons and oligodendrocytes in the CNS. It has been implicated in growth cone collapse and neurite outgrowth inhibition by signaling through the Nogo receptor and paired Ig-like receptor B (PirB). OMgp was also reported to be an extracellular matrix (ECM) protein surrounding CNS nodes of Ranvier and proposed to function as (1) an ...