Background & Aim: Investigation of suspension cell culture and callus production in Catharanthus roseus. Catharanthus roseus is an herbaceous perennial plant belongs to the family Apocynaceae. C. roseus is important as commercial medicinal plant because of its alkaloidal content. Whole plant contains about 130 alkaloids those are classified as vinca alkaloids...

Robertson and Seymour proved that every graph with sufficiently large treewidth contains a large grid minor. However, the best known bound on the treewidth that forces an l × l grid minor is exponential in l. It is unknown whether polynomial treewidth suffices. We prove a result in this direction. A grid-like-minor of order l in a graph G is a set of paths in Gwhose intersection graph is bipart...

Tubulin vinca-domain ligands can inhibit microtubule polymerization, causing cell death in mitosis, and their potential against multiple cancer types has been demonstrated. However, due to drug resistance toxicities, development of novel is still needed. In this study, we determined the high-resolution crystal structures vinorelbine, YXD, Phomopsin A complex with tubulin at 2.5 Å. Additionally,...

Vinca alkaloids used in anticancer therapy are the well-known vinblastine and vincristine as classical antitumor agents. These dimeric molecules consist of two monomers, vindoline catharanthine, which have no particular activity on their own. The goal our research work was to obtain derivatives one these, vindoline, resulted with important antiproliferative effect. This type were hybrids; conju...

Vinflunine is a novel fluorinated Vinca alkaloid currently in Phase II clinical trials, which in preclinical studies exhibited superior antitumor activity to that of two clinically useful Vinca alkaloids, vinorelbine and vinblastine. All three of the drugs block mitosis at the metaphase/anaphase transition, leading to apoptosis. The mechanism of the mitotic block is not known. On the basis of r...

HomePlant DiseaseVol. 105, No. 7First Report of Leaf Blight Caused by Phytophthora ramorum on Periwinkle (Vinca minor) in Washington State, U.S.A. PreviousNext DISEASE NOTE OPENOpen Access licenseFirst U.S.A.M. Elliott, L. Rollins, T. Bourret, and G. ChastagnerM. Elliott†Corresponding author: M. Elliott; E-mail Address: [email protected]://orcid.org/0000-0002-5754-8881Department Plant Path...

Background & Aim: Investigation of suspension cell culture and callus production in Catharanthus roseus. Catharanthus roseus is an herbaceous perennial plant belongs to the family Apocynaceae. C. roseus is important as commercial medicinal plant because of its alkaloidal content. Whole plant contains about 130 alkaloids those are classified as vinca alkaloids...