BACKGROUND Recent studies have shown that minichromosome maintenance (MCM) proteins (Mcm2-7) may be useful proliferation markers in dysplasia and cancer in various tissues. AIMS To investigate the use of Mcm7 as a proliferation marker in 79 lymph node negative prostate cancers and compare it with Ki-67, a commonly used cell proliferation marker. METHODS The percentage of proliferating cells...

Microbiome science has highlighted human and microbial interdependency, offering a radical epistemic shift from the individualistic view of body self. Research accordingly offered to see humans as ‘homo-microbis’ – complex biomolecular networks composed their associated microbes. While social scientists have begun address microbiome science, proliferation commodification homo-microbial episteme...

Blood compatibility of cardiovascular implants is still a major concern. Rapid endothelialization these implant surfaces has emerged as promising strategy to enhance hemocompatibility and prevent complications such thrombus formation restenosis. The successful mostly depends on the migration endothelial cells (ECs), differentiation stem cells, inhibition smooth muscle cell (SMC) proliferation. ...

In 2022, worldwide mpox outbreaks have called attention to virus infection and treatment opportunities using the drugs cidofovir tecovirimat, which target different stages of in-host viral proliferation, respectively production shedding. We propose a new model dynamics that distinguishes between two stages, so as explore distinct effects drugs, we analyse properties behaviour. Reducing order vi...

It has recently been established that memory CD8(+) T cells induced by viral infection are maintained at unexpectedly high frequencies in the spleen. While it has been established that these memory cells are phenotypically heterogeneous, relatively little is known about the functional status of these cells. Here we investigated the proliferative potential of CD8(+) memory T cells induced by Sen...

Acute phase proteins (APPs) and immune responses in pigs after experimental infection with H1N2 swine influenza virus (SwH1N2) were studied. Eight piglets were infected intranasally with SwH1N2. Four served as controls. Antibodies against swine influenza virus (SIV)s were measured by hemagglutination inhibition assay. The proliferation assay was used to measure influenza-specific cell-mediated ...

Liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) are commonly induced by chronic hepatitis C virus (HCV) infection. We aimed to identify and characterize the involvement of previously screened cytokine GDF15 in HCV pathogenesis. We examined the GDF15 expression after HCV infection both in vitro and in vivo. Cultured JFH-1 HCV was used to determine the GDF15 function on virus propag...

Viral infections are often accompanied by extensive proliferation of reactive CD8 T cells. After a defined number of divisions, normal somatic cells enter a nonreplicative stage termed senescence. In the present study we have identified the inhibitory killer cell lectin-like receptor G1 (KLRG1) as a unique marker for replicative senescence of murine CD8 T cells. KLRG1 expression was induced in ...