نتایج جستجو برای: vismodegib
تعداد نتایج: 334 فیلتر نتایج به سال:
The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key signaling effector of the HH pathway that regulates the levels and activity of the Gli family of ...
growth was significantly slowed by MBZ treatment, whereas in untreated controls, tumors extended into the ventricles, resembling the human disease. Overall survival was prolonged by 150% in the SHH allograft model and by 100% in the SHH vismodegib-resistant allograft model. In the group 3 xenograft model, median survival was increased by a striking 129% from 21 to 48 days (P , 1 · 1024; Figure)...
© 2014 Harborside Press® Skin cancer is the most common cancer type in the United States, affecting more than 3 million people nationally (Cirrone & Harris, 2012). Basal cell carcinoma (BCC) and squamous cell carcinoma are the two main types of nonmelanoma skin cancer, while the more serious form, melanoma, is in its own category. An estimated 80% of nonmelanoma skin cancers are BCCs (Sekulic e...
INTRODUCTION Chemoresistance is a major challenge in the treatment of advanced non-small-cell lung cancer (NSCLC). Because the Sonic hedgehog (Shh) pathway is reactivated in NSCLC, we investigated an association between chemoresistance and Shh activation. PATIENTS AND METHODS From a cohort of 178 patients with advanced NSCLC treated with platinum-based chemotherapy as first-line treatment, we...
Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell carcinoma (BCC). Vismodegib, a first-in-class small-molecule inhibitor of hedgehog pathway signaling, is approved by regulatory authorities for the treatment of adults who have metastatic BCC or locally advanced BCC that has recurred after surgery, or who are not candidates for surgery and who ar...
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