The calcidiol (25-hydroxyvitamin D3) 24-hydroxylase is one of the key enzymes in the metabolism of vitamin D. This enzyme acts on both calcidiol and calcitriol (1,25-dihydroxyvitamin D3) to initiate degradation of these potent vitamin D metabolites and is tightly regulated. Calcitriol itself induces this enzyme and acts at the transcriptional level. Transcriptional regulation of genes by calcit...

Vitamin D is an important regulator of phosphate homeostasis. The effects of vitamin D on the expression of renal Na+-dependent inorganic phosphate (Pi) transporters (types I and II) were investigated. In vitamin D-deficient rats, the amounts of type II Na+-dependent Pi transporter (NaPi-2) protein and mRNA were decreased in the juxtamedullary kidney cortex, but not in the superficial cortex, c...

In a previous paper that we co-authored (Ozisik et al. 2021) showed in some cases Vitamin A and D receptor binding sites are present genes associated with Congenital Anomalies of the Kidney Urinary Tract (CAKUT). From finding derived statement sometimes targets same as CAKUT. We here formalization claim, stating all things class “genes CAKUT” have relation type “is as” to thing “targets vitamin...

Dental caries is a multifactorial disease with multiple risk factors. Vitamin D levels (VDLs) and vitamin receptor polymorphisms (VDRPs) have been investigated for this reason. The aim of narrative review to investigate the relation factors affecting deficiency (VDD), VDRP, Early Childhood Caries (ECC) Severe (S-ECC) in children (primary mixed dentition) dental adults (permanent dentition). Add...

The important reactions that occur to the vitamin D molecule and the important reactions involved in the expression of the final active form of vitamin D are reviewed in a critical manner. After an overview of the metabolism of vitamin D to its active form and to its metabolic degradation products, the molecular understanding of the 1alpha-hydroxylation reaction and the 24-hydroxylation reactio...