Intestinal absorption of [3H]phylloquinone was investigated in the unanesthetized rat by the use of a technique of recirculating perfused isolated intestinal segments. Apparent saturation kinetics were found as the concentration of the vitamin in the perfusate was increased in a stepwise fashion from 15 nM to 300 muM. Alkalinization of the perfusate or the addition of 2.5 mM linoleic acid to th...

PURPOSE To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction. METHODS Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in grou...

High-performance liquid chromatographic (HPLC) methods for determining vitamin K contents in oils and margarines, vegetables, fruits and berries, cereals and animal products were developed. These methods were applied to analysing phylloquinone and menaquinone in a total of 87 food items. In addition, the 2 ́,3 ́-dihydrovitamin K1 contents of a few margarines and hydrogenated oils were determined,...