Gap junction-mediated intercellular communication (GJMIC) has been known for a long time to be essential in propagation of electrical impulse in the heart, and the contribution of altered GJMIC to the genesis of arrhythmias has been extensively investigated. However, although it is well known that GJMIC allows the exchange of biologically important molecules between adjacent cells, the pathophy...

During ischemia and reperfusion, with an increase in intracellular Na and a depolarized membrane potential, Ca may enter the myocyte in exchange for intracellular Na via reverse-mode Na -Ca exchange (NCX). To test the role of Ca entry via NCX during ischemia and reperfusion, we studied mice with cardiac-specific ablation of NCX (NCX-KO) and demonstrated that reverse-mode Ca influx is absent in ...

Abstract:   Objectives: Flexion contractures of the proximal interphalangeal joint are of the most common complication result from surgical procedures and traumatic events.  Orthotic interventions for treatment of contractures may include serial splinting, serial casting, dynamic and/ or static progressive orthoses, or a combination of these orthoses.  This study aimed to determine the effect ...

Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P less than 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene.

abstract   background: dupuytren's disease is a fibroproliferative disorder of the palmar fascia   that can result in disabling contractures of the digits. when function is impeded or deformity is disabling, surgical intervention can be considered, wherein a major problem is recurrence ( reported up to 74%). although, the disease occurs predominantly in men of northern european, there are ...

Contracture of the iliotibial band leading to flexion and abduction deformity at the hip is common in residual paralysis after polio. Ober's test has been used to detect this, but it is unreliable and cannot determine the degree of contracture. We describe a new test which quantifies this contracture and can be used for comparative purposes.

The aim of the study was to investigate and compare different kinesitherapy techniques their impact on recovery patients with ischemic stroke. Also, effect kinesiotaping thrombolized patients. Materials Methods. conducted in 2014-2015 at General Hospital for Treatment Blagoevgrad - Neurology Department. contingent consisted 20 patients, 10 whom had an stroke underwent venous thrombolysis (exper...

AMP-activated protein kinase (AMPK) is a major sensor and regulator of the energetic state of the cell. Little is known about the specific role of AMPKalpha(2), the major AMPK isoform in the heart, in response to global ischemia. We used AMPKalpha(2)-knockout (AMPKalpha(2)(-/-)) mice to evaluate the consequences of AMPKalpha(2) deletion during normoxia and ischemia, with glucose as the sole sub...