A careful examination of lips is often neglected by the members of the medical and dental professions; yet the lips reveal a heterogeneous group of lesions ranging from congenital abnormalities to benign and malignant neoplasms. Verruciform Xanthoma (VX) is an uncommon benign inflammatory mucocutaneous condition that occurs in the oral cavity which was first described by Shafer in 1971. It is o...

PURPOSE Leading-edge therapeutic laser technologies are not available at every medical facility; therefore, alternative approaches incorporating novel advances in digital and laser technology into more readily available conventional methods have generated significant research interest. Using a rabbit model, this study investigated whether the algorithm used in the Endpoint Management (EM) softw...

BACKGROUND P38 mitogen activated protein kinase (MAPK) α modulates microglia-mediated inflammatory responses and a number of neuronal physiological processes. OBJECTIVE To evaluate pre-clinically the pharmacological effects in the brain of p38 MAPKα inhibition with a brain-penetrant specific chemical antagonist. METHODS VX-745, a blood-brain barrier penetrant, highly selective p38 MAPKα inh...

Accumulating evidence indicates that secretory phospholipase A2 (sPLA2) enzymes promote atherogenic processes. We have previously showed the presence of Group V sPLA2 (GV sPLA2) in human and mouse atherosclerotic lesions, its hydrolysis of low density lipoprotein (LDL) particles, and the ability of GV sPLA2-modified LDL (GV-LDL) to induce macrophage foam cell formation in vitro. The goal of thi...

The purpose of this project was to determine and compare the time-related changes in blood, brain, and tissue acetylcholinesterase (AChE) activity during the first hour after exposure to six organophosphorus nerve agents (GA, GB, GD, GF, VR, and VX) in Hartley guinea pigs. Animals were pretreated with atropine methyl nitrate (1.0 mg/kg, i.m.) to minimize peripheral toxic effects 15 min before t...