Studies focusing on neuropsychological impairments in Wilson's disease (WD) have highlighted that patients showing neurological signs present significant deficits in a wide range of cognitive domains. Attentional and executive impairments have also been described in people with hepatic WD. However, social cognition abilities, i.e. cognitive processes required to perceive the emotions, intention...

We consider a weak version of R. L. Moore's property D. Roughly speaking, a space X is said to have property D if each discrete (in the locally finite sense) sequence of points in X can be "expanded" to a discrete family of open sets in X. A space is said to have property wD if each discrete sequence has a subsequence which can be "expanded" to a discrete family of open sets. All regular, subme...

We present a theoretical delay time distribution (DTD) of Type Ia supernovae on the basis of our new evolutionary models of single degenerate (SD) progenitor systems. Our model DTD has almost a featureless power law shape (∝ t−n with n ≈ 1) for the delay time from t ∼ 0.1 to 10 Gyr. This is in good agreement with the recent direct measurement of DTD. The observed featureless property of the DTD...

A diet high in saturated fat and similar in composition to western diets (WD) has been shown to exacerbate injury following traumatic brain injury. Thus, we investigated the effects of a WD on cell death and functional outcome following global ischemia. First we assessed the effects of a 60-day WD regimen on temperature, activity and glucose levels in normal rats (Experiment 1). Second, we eval...

CNS WD is fatal if antibiotics are not begun early, but knowledge regarding the variety of presentations on MR imaging is limited. In order to more effectively recognize this entity on MR imaging, the Mayo Clinic medical records were reviewed for subjects diagnosed with CNS WD from 1992-2006 who had also undergone MR imaging of the neuraxis. Seven subjects were identified and their imaging find...

The WD-repeat proteins are found in eukaryotes and play an important role in the regulation of a wide variety of cellular functions including signal transduction, pre-mRNA processing and cytoskeleton assembly. In this study, a cDNA encoding a WD repeat-containing protein 13 (GbWDR13) was cloned by PCR from Ginkgo biloba. The length of GbWDR13 gene is 1500 bp, encoding 496 amino acids. The predi...

BACKGROUND Whipple disease (WD) is an infectious disease, which may affect the central nervous system. Central nervous system symptoms are eventually present in as many as 43% of the cases. To our knowledge, cerebellar ataxia in WD has never been formally studied in any large series. OBJECTIVE To determine the prevalence of cerebellar ataxia in central nervous system WD. RESULTS Between Jan...

PGE(2) plays an important role in the regulation of fluid metabolism chiefly via antagonizing vasopressin-induced osmotic permeability in the distal nephron, but its enzymatic sources remain uncertain. The present study was undertaken to investigate the potential role of microsomal PGE synthase (mPGES)-1 in the regulation of urine concentrating ability after water deprivation (WD). Following 24...

In the Author Contributions section, Nathalie J. M. van Hees (NH), Erik J. Giltay (EG), Thomas Puvill (TP), Nadine Janssen (NJ), and Willem van der Does (WD) all should be listed as one of the persons who wrote the paper. The correct contributions are: Conceived and designed the experiments: NH EGWD. Performed the experiments: NH TP NJ. Analyzed the data: NH EG TP NJ WD ST. Contributed reagents...

The Wigner distribution (WD) is perhaps the most prominent quadratic time–frequency signal representation. In this paper, which has mainly tutorial character but also contains some new results, we describe extensions of the WD concept to multidimensional vector signals, nonstationary random processes, linear time-varying systems (deterministic and random), linear signal spaces, and frames. We d...