Developmental aspects of taurocholate transport into ileal brush border membrane vesicles were studied in 2-wk-old (suckling), 3-wk-old (weanling), and 6-wk-old (adolescent) rats. Taurocholate uptake (picomoles per milligram protein) into brush border membrane vesicles prepared from 2-wk-old rats was similar under Na+ and K+ gradient conditions (outside greater than inside). By contrast, uptake...

In the rat and other species “labile― methyl groups are essential to normal metabolism (5). These are methyl groups which are capable of be ing transferred in toto from one compound to an other by specific enzymes and enzyme cofactors. In the rat the major source of such groups is the diet, which may contain them in the form of such compounds as i@-methionine, choline, betaine, and possibly...

Rat cyclophilin-like protein (Cy-LP) is a candidate hypertension gene initially identified by differential hybridization and implicated in renal mechanisms of salt retention and high blood pressure. We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and an allele-specific polymerase chain reaction primer assay, that CypB but not Cy-LP...

Recent studies indicate that iron (Fe) is involved in neurotoxicity caused by inorganic lead (Pb). We studied the role of Fe in the effects Pb-induced cerebral apoptosis during rat development and to explore its possible regulatory mechanism. In the present study, weanling male Sprague-Dawley rats were randomly divided into four groups. Three groups of rats received 400 microg/mL Pb acetate sol...

I. Weanling (24-d-old) male rats were maintained at their body-weight for I month by restricting the intake of their normal diet. The animals were then rehabilitated for 0, 3 , 7 , 1 0 or 16 d. Control animals weregiven anunrestricted diet and some killed at the same body-weight as the experimental animals and others at the same age. 2. The forebrain, cerebellum, brain stem, heart, lungs, liver...