OBJECTIVE To assess the relation between body mass index and mortality in middle aged British men. DESIGN Men who were recruited for the British Regional Heart Study were followed up for a mean of nine years. SETTING General practices in 24 British towns. SUBJECTS 7735 Men aged 40-59 years selected from the age-sex registers of one group practice in each of the 24 towns. MAIN OUTCOME ME...

The 39-untranslated regions (UTRs) of a group of novel uncapped viral RNAs allow efficient translation initiation at the 59proximal AUG. A well-characterized model is the Barley yellow dwarf virus class of cap-independent translation elements (BTE). It facilitates translation by forming kissing stem–loops between the BTE in the 39-UTR and a BTE-complementary loop in the 59-UTR. Here we investig...

OBJECTIVE To determine the effects on weight loss of three abbreviated behavioral weight loss interventions with and without coaching and mobile technology. METHODS A randomized controlled efficacy study of three 6-month weight loss treatments was conducted in 96 adults with obesity: 1) self-guided (SELF), 2) standard (STND), or 3) technology-supported (TECH). STND and TECH received eight in-...

The impact of amino acid nutrition during lactation on body nutrient mobilization and milk nutrient output in primiparous sows was evaluated. Thirty-six sows, nursing litters of 13 pigs, were allocated daily 6 kg of a fortified corn-soybean meal diet containing a high (HP, 1.20% lysine) or low (LP, .34% lysine) protein content during a 23-d lactation. Dietary lysine concentration was achieved b...

OBJECTIVES To determine the roles of body size and longitudinal body weight changes in the survival of incident peritoneal dialysis patients. PATIENTS AND METHODS Patients (n = 1911) older than 18 years of age recruited from 114 dialysis centers (Dec/ 2004-Oct/2007) and participating in the Brazilian Peritoneal Dialysis Multicenter Cohort Study were included. Clinical and laboratory data were...

AIMS To evaluate fetal growth in relation to gestational weight gain in women with Type 2 diabetes. METHODS A retrospective cohort study of 142 consecutive pregnancies in 28 women of normal weight, 39 overweight women and 75 obese women with Type 2 diabetes (pre-pregnancy BMI < 25, 25-29.9, ≥ 30 kg/m2, respectively). Gestational weight gain was categorized as excessive (exceeding the US Insti...

The distribution of (59)Fe has been investigated in nonpregnant, pregnant and lactating rats and their young after injection of solutions containing a high molecular weight iron-dextrin complex (iron-dextrin, intravenously), and a low molecular weight complex of iron, sorbitol and citric acid (iron-sorbitol, intramuscularly), each labelled with (59)Fe. At different times after injection of a do...