Two secreted signaling molecules, wingless (wg) and decapentaplegic (dpp), are required to specify the heart in Drosophila. wg and dpp are also required to specify other cell types within the mesoderm and in many other regions of the embryo. Because the spatial patterns of wg and dpp are dynamic, different populations of mesodermal cells are exposed to different combinations of wg and/or dpp at...

Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene dally in this process. Here, we report the identification of another Drosophila glypican gene, dally-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene act...

Drosophila Wingless (Wg) is a morphogen that determines cell fate during development. Previous studies have shown that endocytic pathways regulate Wg trafficking and signaling. Here, we showed that loss of vamp7, a gene required for vesicle fusion, dramatically increased Wg levels and decreased Wg signaling. Interestingly, we found that levels of Dally-like (Dlp), a glypican that can interact w...

introduction today, with the increasing population and the need for strategic and industrial crops the farmers are simulated to grow these kinds of crops. thus, this subject has now been caused the inappropriate use of land and natural resources. on the other hand, the natural environment resources have limited the ability to use its resources and the climate change intensifies this limit abili...

climate change is one of the most important factors that will affect different parts of human life on earth and will be adverse effects on environmental resources, economic, social and especially water resources, with changes in rainfall and timing of runoff amount.one of the strategies to mitigate the effects of climate change is to assess its effects on precipitation, temperature and runoff i...

This case presentation explores how two key Drosophila morphogens, Decapentaplegic (Dpp) and Wingless (Wg), control the expression of two wing disc transcription factors, Vestigial (Vg) and Distalless (Dll). Two simple models for the potential control of Vg and Dll expression by Dpp and Wg in the mature steady state Drosophila wing pouch are explored. Firstly, a model based on the activation me...

Wnts and bone morphogenetic proteins (BMPs) are signaling elements that are crucial for a variety of events in animal development. In Drosophila, Wingless (Wg, a Wnt ligand) and Decapentaplegic (Dpp, a BMP homolog) are thought to function through distinct signal transduction pathways and independently direct the patterning of the wing. However, recent studies suggest that Mothers against Dpp (M...