Background: Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions the regulation of immunity are mediated by receptors (VDRs). Polymorphisms VDR gene have associated with several health outcomes; however, their effects on still need more clarification. This study aims to investigat...

The single gene mutation tau in the Syrian hamster-apart from its effect on the circadian organization of locomotor activity--has a pronounced influence on body weight. In this study we investigate the impact of maternal and pup genotypes at the tau-locus on the growth rate of pups. Homozygous tau mutant hamsters (circadian period of 20 hours) had lower growth rates and adult body weights than ...

Botryosphaeria dothidea is a widespread and economically important pathogen on various fruit trees, and it often causes die-back and canker on limbs and fruit rot. In characterizing intraspecies genetic variation within this fungus, group I introns, rich in rDNA of fungi, may provide a productive region for exploration. In this research, we analysed complete small subunit (SSU) ribosomal DNA (r...

The aim of this study was to establish the manner in which the LEPR 223, 1019, 492, and 976 gene polymorphisms influence child obesity.We performed a prospective case-control study on 264 hospitalized children from Romania (Nutrichild study) whom we divided into 2 groups: Group I -143 controls and Group II-121 obese children.The 2 groups were evaluated regarding the anthropometry (MUAC, TST, H/...

Thymidylate synthase (TS), the target enzyme of the fluoropyrimidine class of drugs, has a 28-bp repeat polymorphism in the promoter region that has been associated with response of tumors to 5-fluorouracil-based therapy. Patients homozygous for the double repeat (2R/2R) in the TS gene have an overall better outcome from treatment than patients homozygous for the triple repeat (3R/3R). However,...

We simulate the magnetosphere of the nearby millisecond pulsar PSR J0437-4715, which is expected to have an unscreened electric potential due to the lack of magnetic pair production. We incorporate General Relativistic (GR) effects and study curvature radiation (CR) by primary electrons, but neglect inverse Comp-ton (IC) scattering of thermal X-ray photons by these electrons. We find that the C...