Background Alzheimer’s disease (AD) is highly heritable. Genome-wide association studies and whole genome sequencing have uncovered many AD-risk variants but are still falling short from providing an explanation of the full heritability. To address this issue, we devised a novel deep learning approach that can quantify polygenic risk score (PRS) genetic their interactive effects at individual l...

The problem of identifying complex epistatic quantitative trait loci (QTL) across the entire genome continues to be a formidable challenge for geneticists. The complexity of genome-wide epistatic analysis results mainly from the number of QTL being unknown and the number of possible epistatic effects being huge. In this article, we use a composite model space approach to develop a Bayesian mode...

Understanding the genetic architecture of complex traits requires identification of the underlying genes and characterization of gene-by-gene and genotype-by-environment interactions. Behaviors that mediate interactions between organisms and their environment are complex traits expected to be especially sensitive to environmental conditions. Previous studies on the olfactory avoidance response ...

Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genomewide scans for pairwise epistasis in five independent celiac disease (CD) case-control studies, using a rapid model-free approach to examine over 500 billion SNP pairs in total. We found 5,359 significa...

IN THE INITIAL DISSECTIONS of blood pressure (BP) into its genetic components using hypertensive inbred Dahl salt-sensitive rats (SS/Jr, referred to hereafter as S rats), gene-gene interactions and genetic background effects were evident. The effects of alleles at different genetic loci on a quantitative trait such as BP can be additive (plus or minus), or the combined effects can be higher or ...

diallel crosses of eight genotypes of safflower were conducted and f1 and f2 generations were evaluated to estimate genetic parameters for seed-quality related traits including protein contents (%), fiber, ash and oil yeild. griffing’s methods 1 and 2 for f1 and f2 generations was used, respectively. sixty four genotypes including 8 parents and 56 f1 progenies, and half diallel crosses of f2 ge...

Carlborg, Ö. 2002. New Methods for Mapping Quantitative Trait Loci. Doctoral dissertation. ISSN 1401-6257, ISBN 91-576-6362-9 This thesis presents and discusses the use of various genetic models, high performance computing, global optimization algorithms and statistical methods for mapping Quantitative Trait Loci (QTL). The aim of the work has been to develop statistically powerful and computat...

A fundamental goal of the biological sciences is to determine processes that facilitate the evolution of diversity. These processes can be separated into ecological, physiological, developmental and genetic. An ecological process that facilitates diversification is frequency-dependent selection caused by competition. Models of frequency-dependent adaptive diversification have generally assumed ...