BACKGROUND Making peptide pharmaceuticals involves challenging processes where many barriers, which include production and manufacture, need to be overcome. A non common but interesting research area is related to peptides with intracellular targets, which opens up new possibilities, allowing the modulation of processes occurring within the cell or interference with signaling pathways. However,...

Recombinant clathrin protein fragments form assemblies that template gold nanocrystals in an array across the latticed surface. The nanocrystals exhibit unusual anisotropic morphologies with long range ordering, both of which are dependent upon the presence of a hexahistidine tag on the clathrin heavy chain fragments.

One of the things for which Donald Rumsfeld will be remembered is his distinction between ‘known knowns’, ‘known unknowns’ and ‘unknown unknowns’. He was speaking in 2002, at a press conference where he was commenting on the absence of evidence linking the government of Iraq with the supply of weapons of mass destruction to terrorist groups: There are known knowns; there are things we know that...

The organisms of the genus Lysobacter have been recognized as prolific producers of bioactive secondary metabolites, making them potentially valuable as biocontrol agents and as sources of compounds for drug leads. This study was aimed at understanding the regulatory mechanisms that underlie the production of secondary metabolites in our study organism, Lysobacter enzymogenes. Since secondary m...

This paper examines the changing methods, underlying motives, clienteles and controversy surrounding posthumous commemorations of Lord Lister in Britain. The importance of the commemorations for professional identity formation continues throughout the twentieth century, but World War I appears as a turning point. The constituencies commemorating Lister change from broadly international, nationa...

Acknowledgement I am most grateful to my Lord and God Jesus Christ who is truly worthy of all praise. I especially praise and thank Him for all His help concerning this work. I am also very grateful to Jun. Prof. Dr. Stefan Ruzika for his help and guidance and especially for his patience. I also thank Heike Sperber for sharing her knowledge of series-parallel graphs with me.

Lord Horder, in his address to the West London Medico-chirurgical Society in 1949, posed the question “Whither medicine?” and replied “Why, whither else but straight ahead, forging still more weapons with which to conquer disease, taking still more toll of science in the interest of humanity, adding more and more culture to more and more learning, improving both the art and the crafts. Medicine...

Dedication To my Father, Who is in heaven. To my Brother, through Whom all things came into being. To my Helper, Who teaches me all things. I will lift up my eyes to the mountains; From where shall my help come? My help comes from the LORD, Who made heaven and earth. Acknowledgements First, I would like to thank Dr. Daniel Dix, my thesis advisor, who has patiently guided me through this long pr...

Praise be to God, Lord of the worlds, praise thankful, who says in His Mighty Book (7) And [remember] when your proclaimed, 'If you are grateful, I will surely increase [in favour]; but if deny, indeed, my punishment is severe.'" The emergence objective interpretation as a science-independent breakthrough for seeker knowledge and researcher, hence, research dealt with this entitled (The Moderni...

the concept of logos is seen figuratively before christianity in ancient greek philosophy and judaism (old testament and some works of filon of alexandria). in ancient greek philosophy, logos is counted as the first principle, at least up to the middle platonism period, and more importantly, until the platonism period; that is to say, as it will be pointed out, logos was the first principle wit...