previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. in addition, glucocorticoid receptor (gr) inhibitors improved memory perfor-mance in morphine withdrawal mice. since mineralocorticoid receptor (mr) and grs complement each other, the aim of the current study was to evaluate the effects of spironolactone on ...

Alcohol withdrawal is a common clinical condition that has a variety of complications and morbidities. The manifestations can range from mild agitation to withdrawal seizures and delirium tremens. The treatments for alcohol withdrawal include benzodiazepines, anticonvulsants, beta-blockers and antihypertensives. Although benzodiazepines are presently a first-line therapy, there is controversy r...

In the selective withdrawal experiment fluid is withdrawn through a tube with its tip suspended a distance S above an unperturbed two-fluid interface. At low withdrawal rates, Q, the interface forms a steady state hump and only the upper fluid is withdrawn. When Q is increased (or S decreased), the interface undergoes a transition so that the lower fluid is entrained with the upper one, forming...

This report describes the development of a test method and predictive model to estimate the residual bending strength of fire-retardant-treated plywood roof sheathing from measurement of screw-withdrawal force. The preferred test methodology is described in detail. Models were developed to predict loss in mean and lower prediction bounds for plywood bending strength as a function of a screw-wit...

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

BACKGROUND: Inhalants are among the most common and dangerous forms of substance use, but very little research on inhalant use disorders exist. Unlike other substances, the Diagnostic and Statistical Manual, 4th edition (DSM-IV) indicates that inhalants do not have an associated withdrawal syndrome among persons who meet criteria for inhalant dependence. METHODS: Using data from the National E...

At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study Suzanne Bennett Johnson*, Kristian F. Lynch, Hye-Seung Lee, Laura Smith, Judith Baxter, Barbro Lernmark, Roswith Roth, Tuula Simell, and the TEDDY Study Group Department of Medical Humanities and Social Sciences, Florida State University College of Medicine, 1115 West Call...