Our study aimed at developing clinical thresholds (cut-off scores) for the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index, EQ-5D and Knee Society Score for discriminating between patients with and without treatment success following total knee arthroplasty (TKA). We performed a retrospective analysis of 1055 patients 2 months after TKA and 765 patients 1 year after TKA. ...

Clinical measurement in both clinical research and clinical practice requires tools and techniques that are valid, reliable and responsive. Patient-centred self-reported measures provide opportunity to evaluate consequences of osteoarthritis, that are important and relevant to patients with the condition. The WOMAC and AUSCAN Indices are health status measurement questionnaires that are valid, ...

Purpose: To assess the efficacy and safety of single-dose, intra-articular (IA) administration UBX0101 in patients with painful knee osteoarthritis (OA). is a p53/MDM2 interaction inhibitor that can induce apoptosis senescent synoviocytes. Results from recent Phase 1 study (NCT03513016) suggested IA had dose-dependent, clinically meaningful effects on pain function OA. Methods: This was 2, rand...

Purpose: To determine whether enablement was a moderator of the effect chronic back and knee pain on health-related quality life (HRQOL). Methods: This cross-sectional study 1319 Chinese primary care patients with problems who completed Patient Enablement Instrument-2 (PEI-2), Western Ontario McMaster University Osteoarthritis Index (WOMAC), Pain Rating Scale (PRS). Multivariable regression exa...

  Background: We aimed to develop and validate the Persian version of Short Form McGill Pain Questionnaire-2 (SF-MPQ-2) in patients with knee osteoarthritis. Methods: Translation and back translation was performed using Beaton’s guideline. After a consensus has achieved on the Persian version of SF-MPQ-2, it was administered to 30 patients with knee osteoarthritis in a pilot study. Then, we enr...

Background: Short-wave diathermy (SWD) is an electrotherapeutic modality used in the conservative treatment of knee osteoarthritis (KOA).  Electromagnetic radiation delivered in continuous (cSWD) or pulse (pSWD) mode provides a deep heating effect on tissues.  There is no consensus on outcomes of treatment with cSWD versus pSWD in KOA. The aim of this study was to compare the effects of cSWD ve...

OBJECTIVE To assess the practicality, validity and responsiveness of using each of two utility measures (the EQ-5D and SF-6D) to measure the benefits of alleviating knee pain. METHODS Participants in a randomised controlled trial, which was designed to compare four different interventions for people with self-reported knee pain, were asked to complete the EQ-5D, SF-6D, and Western Ontario and...