ED FROM Blume PA, Walters J, Payne W, et al. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care 2008;31:631–6. Correspondence to: Dr P A Blume, North American Center for Limb Preservation, New Haven, CT, USA; [email protected] Source of fun...

Pilonidal sinus disease (PSD) is a common chronic, benign disease of young adulthood. Pilonidal disease is an infection under the skin in the gluteal cleft. Pilonidal literally means a „„nest of hair”. Known risk factors include family history, local trauma, sedentary occupation, and obesity. Pilonidal sinus disease is a blind track, which extends from the skin of natal cleft up to the presacra...

Actomyosin contraction powers the sealing of epithelial sheets during embryogenesis and wound closure; however, the mechanisms are poorly understood. After laser ablation wounding of Madin-Darby canine kidney cell monolayers, we observed distinct steps in wound closure from time-lapse images of myosin distribution during resealing. Immediately upon wounding, actin and myosin II regulatory light...

Following a total knee replacement surgery, a 51-year-old insulin-dependent patient presented with complications of impaired healing and postoperative trauma to the wound site. The inability of this leg wound to heal placed this patient at risk of amputation. Vacuum-assisted closure therapy was initiated at postoperative day 53; after 100 days of protracted wound history a series of treatments ...

BACKGROUND Repair of skin wounds is essential for animals to survive in a harsh environment, yet the signaling pathways initiating wound repair in vivo remain little understood. In Caenorhabditis elegans, a p38 mitogen-activated protein kinase (MAPK) cascade promotes innate immune responses to wounding but is not required for other aspects of wound healing. We therefore set out to identify addi...

Introduction: Wound debridement is considered essential in chronic wound management. Hypochlorous acid has been shown to be an effective agent in reducing wound bacterial counts in open wounds. Ultrasound-enabled wound debridement is an effective and efficient method of debridement. This study compared ultrasound irrigation with hypochlorous acid versus saline irrigation for wound debridement o...

BACKGROUND The efficacy of negative-pressure wound therapy as a bridge to definitive closure of traumatic extremity wounds has been demonstrated in adults. Gauze-based negative-pressure wound therapy has been used to facilitate granulation tissue formation and promote closure in a number of wound types. In this study, the authors evaluated the efficacy of gauze-based negative-pressure wound the...

Wound healing involves multiple cell signaling pathways, including those regulating cell-extracellular matrix adhesion. Previous work demonstrated that arachidonate oxidation to leukotriene B(4) (LTB(4)) by 5-lipoxygenase (5-LOX) signals fibroblast spreading on fibronectin, whereas cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E(2) (PGE(2)) formation facilitates subsequent cell migration. We...

www.thelancet.com Published online July 16, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60687-0 1 In The Lancet, Eva Deerenberg and colleagues’ prospective, multicentre, double-blind, randomised controlled STITCH trial shows that the rate of incisional hernia is lower with small tissue bites than with large bites. This fi nding contradicts what surgeons have thought and been taught for many de...

OBJECTIVE To compare the difference in the rate of surgical wound infection, patient's convenience and length of hospital stay between Primary Closure and Delayed Primary Closure in cases of complicated appendicitis in adults. METHODS This randomised control trial was conducted at the Combined Military Hospital, Kharian and Malir from June 5, 2006, to September 10, 2009. Patients > or = 15 ye...