INTRODUCTION Leptin, a 16 kDa circulating anti-obesity hormone, exhibits many physiological properties. Recently, leptin was isolated from saliva; however, its function in the oral cavity is still unclear. In this study, we investigated the physiological role of leptin in the oral cavity by focusing on its effect on wound healing in the oral mucosa. METHODS Immunohistochemical analysis was us...

Non-healing skin ulcers are often resistant to most common therapies. Treatment with growth factors has been demonstrated to improve closure of chronic wounds. Here we investigate whether lyophilized culture supernatant of freshly isolated peripheral blood mononuclear cells (PBMC) is able to enhance wound healing. PBMC from healthy human individuals were prepared and cultured for 24 hours. Supe...

objective(s) wound licking has been shown to advance wound healing among humans and many other animals. the present study evaluates the licking effects on healing of skin wound in rats. materials and methods twenty four rats were assigned to 4 different groups randomly and two 3 cm longitudinal full thickness incisions were made on each dorsal and ventral side of rats. the ventral incisions wer...

objective(s) the process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. systemic administration of l-arginine promotes wound healing but its global side effects are undesirable. to confine the action of l-arginine at the site of injury, we tested the effects of local administration of l-arginine on the healing of excision...

the purpose of this study was to evaluate the effects of different time combinations of dexamethasoneand acetylcysteine on experimentally induced corneal ulcers in dogs. experimental corneal wounds werecreated surgically to the anterior one third of the cornea in the center of all eyes of 15 mixed breed dogs. the eyes were divided into five groups according to planned post-operative medications...

conclusions it seems that applying prp is an effective therapeutic approach for wound healing, and faster wound healing is expected due to the presence of more platelets and growth factors. results at the end of study, the prp group showed a greater reduction in the edema ecchymosed discharge approximation (reeda) score compared to the control group (85.5% reduction in the prp group; 72% in the...

results totally, 93.3% of lesions in the s.c group healed in the first 6 hours, while this rate was 40% in c.o group (p < 0.001). the healing ratio for improvement in the first 6 hours was 7 times more in the s.c group. in addition, 90% of infants in the sc group and 36.7% in the c.o group were improved completely in the first 3 days (p < 0.001). patients and methods a randomized, double blind,...

healing of skin wound is a multi-factorial and complex process. proper treatment of diabetic wounds is still a major clinical challenge. although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. the aim of this study was to evaluate healing of ovine excisional diabetic wound model. eight 4-month-old iranian makoui wethers were equa...

results the average percentage of wound healing in different groups on days 3, 6, 9 and 12 were as follows; 21.3%, 37.87%, 67.39% and 77.17% in control group; 24.98%, 34.21%, 70.74% and 88.55% in positive control group; and 32.35%, 61.27%, 94.53%, and 99.91%, in case group. a significant difference was observed between the control and case groups (p < 0.05). conclusions treatment with the studi...