croton guatemalensis lotsy (cgl), known as “copalchi” in chiapas, mexico, is used for the treatment of fever, abdominal pain and malaria and also as a remedy for chills and for treating rheumatism. the aim of this study was to evaluate whether aqueous extracts from the bark of this plant possesses indeed antinociceptive properties by using two different animal models of nociception, the acetic ...

Zinc is concentrated in the dorsal horn of the spinal cord and has been proposed to alter excitability of primary afferent C-fibers, structures believed to be important in nociceptive transmission. Based on the inhibitory effect of zinc on the activity of various other neurotransmitters that play a role in nociception, we tested the hypothesis that zinc modulates pain transmission. To test this...

BACKGROUND Opuntia elatio Mill is a xerophytic plant with potentially active nutrients. It is traditionally appreciated for its pharmacological properties; however, the scientific information on this plant is insufficient. OBJECTIVE The present study evaluates the antinociceptive and anti-inflammatory action of prickly pear. MATERIALS AND METHODS Writhing and tail-immersion tests were carri...

A novel series of 3-(2-amino-6-pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (5a-5j) were synthesized from 3-acetyl-6-bromo-2H-chromen-2-one (3). The structures of the synthesized compounds were elucidated by IR, H-NMR, C-NMR, and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo analgesic activity at a dose of 20 mg/kg body weight. Among them, compounds 5a, 5b and 5...

Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant...

Isodon rugosus Wall. ex Benth. is extensively used as traditional medicine for the management of various types of pain including tooth ache, gastric pain, abdominal pain, ear ache, and generalized body pain. The current study is designed to scientifically verify the purported uses of I. rugosus as analgesic agent and to figure out its possible mechanism of action. Bioactive compounds responsibl...

BACKGROUND The antinociceptive effect of an aqueous extract from the leaves of Toona sinensis (TS, [A. Juss., M. Roem.]) was studied using the writhing test in mice. METHODS Different extraction fractions from TS leaf extracts (TSL1 to TSL5) were administered orally 1 h before intraperitoneal injection of acetic acid. RESULTS After treatment with TSL1, TSL2, TSL3, TSL4, and TSL5 at a dose o...

Leaf methanol extract of C. orbiculata L. was investigated for antinociceptive and anti-inflammatory activities using acetic acid writhing and hot-plate tests and carrageenan-induced oedema test in mice and rats, respectively. C. orbiculata (100-400 mg/kg, i.p.) significantly inhibited acetic acid-induced writhing and significantly delayed the reaction time of mice to the hot-plate-induced ther...

The present study was conducted to evaluate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of whole fruit of Lagenaria breviflora (LB) in rat and mice. Analgesic activity was measured by hot plate, formalin-induced paw licking, and acetic acid-induced abdominal writhing tests, while anti-inflammatory activity was determined by inhibition of carrageenan-induced paw o...

Ethanolic extract of Tabernaemontana divaricata L. (TD) flowers were evaluated for analgesic and antiinflammatory effects on Wistar rat model. Analgesic and anti-inflammatory potential of TD flowers at doses of 125, 250 & 500 mg/kg was evaluated against the standard drug indomethacin at a dose of 20 mg/kg, p.o. Wistar rats of either sex of 6 numbers in each group was undertaken for study and ev...