Two diketopiperazines, XR334 (1) and the novel compound XR330 (2), were isolated from the lyophilised biomass of an unidentified Streptomyces sp. Their structures were elucidated on the basis of spectroscopic studies and confirmed by chemical synthesis. Both compounds inhibited plasminogen activator inhibitor-1 activity in an amidolytic assay of tissue plasminogen activator mediated plasmin gen...

background: the goals of the present research were to investigate the rectal dose during four chosen techniques of cervical cancer radiotherapy and to examine how accurately the treatment planning represents dose measurements, and it’s practicality for routine use as well as, to determine the homogeneity of dose in tumor volume. materials and methods: the study was carried out using a nepton 10...

BACKGROUND Open-label quetiapine coadministration with SSRI therapy, in a diagnostically mixed sample of comorbid anxiety patients, offered additional anxiolytic benefit. Therefore, we designed the following controlled trial to confirm these findings in a comorbid, SSRI-resistant, panic disorder (PD) patient sample. METHODS This was a single-site, double-blind, placebo-controlled (PLAC), rand...

OBJECTIVES Once-monthly intramuscular extended-release naltrexone (XR-NTX) has demonstrated efficacy for the prevention of relapse in opioid dependence, providing an alternative to agonist or partial agonist maintenance (ie, methadone and buprenorphine). The question remains, for whom is this unique treatment most efficacious and can patient-treatment matching factors be identified? METHODS A...

OBJECTIVE THIS STUDY COMPARED ADHERENCE AND PERSISTENCE OF THREE BRANDED ANTIDEPRESSANTS: the serotonin and norepinephrine reuptake inhibitors (SNRIs) duloxetine and venlafaxine XR, and the selective serotonin reuptake inhibitor (SSRI) escitalopram; and generic selective SSRIs, and examined demographic and clinical predictors of adherence and persistence in patients with major depressive disord...

BACKGROUND Some studies have indicated the efficacy of quetiapine in the treatment of generalized anxiety disorder (GAD). OBJECTIVE The purpose of this study was to systematically review the efficacy, acceptability, and tolerability of quetiapine in adult patients with GAD. METHODS The SCOPUS, MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases ...

Extended reality (XR) technology, which includes virtual (VR), augmented (AR), and 14 virtuality (AV), allows people to interact with content in new ways. explore different recruitment strategies, using evidence that a personal connection between 57 researcher participant reduces non-attendance, find remote process 58 short pre-experiment online meeting boosts attendance. 59While having further...

Abstract Utopian images in XR-games are often ambiguous. How can ambiguity be consciously designed virtual worlds? What the design principles for game designers? Ambiguity arises from discontinuity and decontextualization, deliberate omission of facts, skillful superimposition contradictory codes. An ontology interactive media explains elusive visual poetry image perception. The five basic elem...

The study aimed to summarize clinical data for escitalopram in the treatment of major depressive disorder in primary care. Medline, Embase and Cochrane databases were searched for randomized controlled trials of escitalopram (10-20 mg/day for 8 weeks) versus other antidepressants in therapeutic doses or placebo. Patients were required to have had moderate/severe depression, with Montgomery-Asbe...