Herein, we present a rare case of acute myeloid leukemia (AML) with CBFA2T3-rearrangement and the expression megakaryocytic lymphoid markers, highlighting need for high suspicion index in differential diagnosis applying adequate workup to avoid misdiagnosing this entity. CBFA2T3::GLIS2-positive AML is primarily found infants non-down syndrome megakaryoblastic (non-DSAMKL). Flow cytometry immuno...

Neuropeptide Y (NPY), a regulatory peptide in both the central and peripheral nervous systems, has recently been found in neuroendocrine tumors as well as in the bone marrow of rat and certain autoimmune mice, but not in human bone marrow. To investigate a possible role for NPY in the human hematopoietic system, we have prospectively studied NPY-like immunoreactivity in plasma (P-NPY-LI) and NP...

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate children with hemato-oncological diseases unknown. Here we report clinical case of an 8-year-old female patient B-cell lymphoblastic leukemia as well heart that resolved during specific therapy for the cancer. The patient's parents gave consent to use their child's data, incl...

introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...

introduction: acute leukemia is the most common malignancy in children and acute lymphoblastic leukemia (all) accounts for 75% of acute leukemia cases. new treatment protocols have resulted in complete remission rates up to nearly 100% in children with acute lymphoblastic leukemia. today, one of the most important prognostic factors in acute lymphoblastic leukemia is intensity of the treatment....

Cytogenetic studies were performed on ML cell lines (ML-1, -2, and -3), as well as on the leukemic cells of a patient from whom the ML cells were derived. The ML-1 cell line showed numerical and structural cytogenetic changes, i.e., -Y, 1p-, 6q-, 11q-, +12, +13q+, 14q-, and 17q-. The ML-2 cell line had two copies of the 13q+, whereas the ML-3 cells contained three clones, i.e., 47,X,-Y,1p-,6q-,...

1. Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD. Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 1997; 89:2067-78. 2. Ott G, Kalla J, Ott MM, et al. Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood 1997; 89:1421-9. 3. Norton AJ, Matthews J, Pappa V, et al. M...

Adult T-cell Leukemia/Lymphoma (ATLL) is a rare aggressive malignancy associated with human leukemia virus type 1 (HTLV-1) infection. However, little known about the underlying activated molecular pathways at single cell level. Moreover, intercellular communications between tumor microenvironment (TME) and cells in this are currently unknown. Difficulties harvesting fresh tissue clinical settin...

background: interaction between killer cell immunoglobulin-like receptors (kir) and human leukocyte antigen (hla) class i molecules is important for regulation of natural killer (nk) cell function. objective: the aim of this study was to investigate the impact of compound kir-hla genotype on susceptibility to acute leukemia. methods: cohorts of iranian patients with acute myeloid leukemia (aml;...