The multifunctional Y box-binding protein 1 (YB-1) is transcriptionally repressed by the oncogenic phosphoinositide 3-kinase (PI3K) pathway (with P3K as an oncogenic homolog of the catalytic subunit) and, when reexpressed with the retroviral vector RCAS, interferes with P3K- and Akt-induced transformation of chicken embryo fibroblasts. Retrovirally expressed YB-1 binds to the cap of mRNAs and i...

Gene amplification of HER2/ErbB2 occurs in gastric cancer and the therapeutic efficacy of the HER2-targeted antibody, trastuzumab, has recently been improved against HER2-positive advanced stomach cancer. Here, we examined whether Y-box-binding protein-1 (YB-1) could selectively control HER2 gene expression and cellular sensitivity to EGF receptor (EGFR) family protein-targeted drugs in human g...

Yb 3d and valence-band photoemission spectra of the first-order valence-transition compound YbInCu4 have been measured with hard x ray at an excitation energy of 5.95 keV. Abrupt changes are clearly observed in both spectra around the transition temperature T(V)=42 K, in comparison with ultraviolet and soft x-ray photoemission (VUV-PES and SX-PES) spectra. From the Yb 3d spectra, the Yb valence...

The modification effect of the doping of Yb ions, as an auxiliary activator, onto the luminescent properties of SrAl2O4:Eu , Dy phosphor was studied for the first time. The phosphorescent nanoparticles were prepared by the combustion method. The experimental results indicate that the appropriate doping of Yb ions largely improves phosphorescence of the phosphors with more intense luminescence, ...

1≤i≤m yibi. Now let P = {x ∈ (R) | Ax ≤ b and x ≥ 0}. Suppose x is a feasible point for our primal linear programming problem, so x ∈ P , i.e., Ax ≤ b and x ≥ 0. Also suppose we can choose y1, . . . , ym defining an m-covector y such that (yA)i ≥ ci and yi ≥ 0 for i = 1, . . . , n. Then c x ≤ yAx, and we have yAx ≤ yb, so altogether we have cx ≤ yAx ≤ yb. We see that yAx and yb are both upper-b...

We report the first efficient trapping of rare-earth Yb atoms with a high-power violet laser diode (LD). An injection-locked violet LD with a 25 mW frequency-stabilized output was used for the magneto-optical trapping (MOT) of fermionic as well as bosonic Yb isotopes. A typical number of 4 × 10 atoms for Yb with a trap density of ∼ 1 × 10/cm was obtained. A 10 mW violet external-cavity LD (ECLD...

A high-efficiency fiber laser at 1018 nm using homemade Yb-doped phosphosilicate fiber is demonstrated. The fiber shows blueshifted emission spectrum compared to Yb-doped aluminosilicate fiber, and is considered favorable for the short wavelength Yb-doped fiber laser. With a 7 m gain fiber, up to 22.8 W output at 1018 nm is achieved with an optical efficiency of 53%. The amplified spontaneous e...

Nuclear factor (NF)-YB, a subunit of the transcription factor nuclear factor Y (NF-Y) complex, binds and activates CCAAT-containing promoters. Our previous work suggested that NF-YB may be a mediator of topoisomerase IIα (Top2α), working through the Top2α promoter. DNA topoisomerase II (Top2) is an essential nuclear enzyme and the primary target for several clinically important anticancer drugs...

[1] Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses of B and Li in serpentinized peridotites from the Feather River Ophiolite (California) indicates that B is enriched in serpentine minerals compared to the whole-rock and less altered olivine grains, while Li in serpentine is depleted or comparable to whole-rock Li. The high B contents of serpentine minerals cor...

Barley stripe mosaic virus contains seven genes, one of which specifies a 17-kD cysteine-rich protein, yb, that is known to affect virulence. To further characterize the role of yb in pathogenesis, we mutagenized sequences encoding amino acids within two clusters of cysteine and histidine residues in the cysteine-rich domain and a group of basic amino acids located between the clusters and dete...