The zipper is a well known design pattern for providing a cursor-like interface to a data structure. However, the classic treatise by Huet only scratches the surface of some of its potential applications. In this paper we take inspiration from Huet, and describe a library suitable as an underpinning for structured editors. We consider a zipper structure that is suitable for traversing heterogen...

Transcriptional activation often requires the rapid assembly of complexes between dimeric transcription factors and specific DNA sites. Here we show that members of the basic region leucine zipper and basic region helix-loop-helix zipper transcription factor families follow an assembly pathway in which two protein monomers bind DNA sequentially and form their dimerization interface while bound ...

Programs in functional programming languages with algebraic datatypes are often datatype-centric and use folds or fold-like functions. Incrementalization of such a program can significantly improve its performance. Functional incrementalization separates the recursion from the calculation and significantly reduces redundant computation. In this paper, we motivate incrementalization with a simpl...

In many distributed applications, pairs of predicates and data have to be evaluated locally. This includes publish-subscribe, keyword search for documents, and selection queries on tuples. We will present the Bit Zipper Rendezvous as a peer-to-peer based solution to these problems. Though not as efficient as value-based partitioning approaches, the Bit Zipper’s generality complements them. Wher...

Using protein stitchery with appropriate attachment of cysteines linking to either C or N termini of the basic region of the v-Jun leucine zipper gene-regulatory protein, we constructed three dimers--pCC, pCN, and pNN. All three bind specifically to the appropriately rearranged DNA recognition sites for v-Jun: ATGAcgTCAT, ATGAcgATGA, and TCATcgTCAT, respectively (Kd, approximately 4 nM at 4 deg...

In this paper we investigate the peak-to-average power ratio (PAR) and its effects on the performance of Zipper-VDSL systems. The spectrum and the out of band power when passing through a nonlinear device is also investigated. We further evaluate the performance with a recently proposed PAR reduction technique for orthogonal frequency division multiplexing (OFDM). PAR reduction of Zipper-VDSL m...

This paper proposes a lossless compression scheme for greyscale images using Zipper Transformation (ZT) and Inverse Zipper Transformation (iZT). The proposed transformation exploits the conjugate symmetry property of DFT. We benchmark the proposed ZT with both Discrete Cosine Transformation (DCT) and Fast Walsh Hadamard Transformation (FWHT) in order to quantify the efficacy of the proposed tra...

We previously reported that a helical trigger segment within the GCN4 leucine zipper monomer is indispensable for the formation of its parallel two-stranded coiled coil. Here, we demonstrate that the intrinsic secondary structure of the trigger site is largely stabilized by an intrahelical salt bridge. Removal of this surface salt bridge by a single amino acid mutation induced only minor change...

The algorithm here described concerns generation, visualization, and modification of molecular nanostructures of single-walled nanotubes (NTs) of particular configurations (armchair, zipper, multiple zipper, zigzag, or chiral) by means of a Graphical User Interface (GUI). NTs are made from a carbon graphene sheet created according to certain parameters defining required nanostructures. Generate...