OBJECTIVE To evaluate the efficacy, safety and tolerability of daily doses of 25, 50, and 100 mg of zonisamide (ZNS) administered as adjunctive treatment in patients with Parkinson disease (PD). METHODS We conducted a multicenter, randomized, double-blind, parallel-treatment, placebo-controlled study in Japan. Patients with PD who showed insufficient response to levodopa treatment were given ...

Anticonvulsants are a class of medications that have received considerable interest as possible treatments in patients with behavioural disturbances in dementia. The role of these medications for such a use remains controversial. The current paper reviews the published evidence surrounding the safety and efficacy (i.e. as a behavioural and cognitive treatment) of newer anticonvulsants in patien...

Our research in 2010 included the following: 1) an actigraphic study of tremor treated with zonisamide in patients with Parkinson’s disease (PD), 2) a study of autonomic dysfunction in neurodegenerative disease, 3) neurophysiological studies of the visual information processing functions in neurodegenerative disease and of diabetic polyneuropathy, 4) neuroradiological studies with nuclear medic...

Transient splenial lesion (TSL) of the corpus callosum is associated with various disorders, including encephalitis, seizure and metabolic disturbances (1). We herein report a patient showing TSL after switching antiepileptic medications. A 46-year-old woman with epilepsy had been taking carbamazepine for decades. Asymptomatic hyponatremia (125 mEq/L) was detected, and carbamazepine was switche...