At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study Suzanne Bennett Johnson*, Kristian F. Lynch, Hye-Seung Lee, Laura Smith, Judith Baxter, Barbro Lernmark, Roswith Roth, Tuula Simell, and the TEDDY Study Group Department of Medical Humanities and Social Sciences, Florida State University College of Medicine, 1115 West Call...

A study investigating the validity of Mobley's (1977) model of the intermediate linkages in the turnover decision process among employees working in two diverse settings yielded a pattern of results generally consistent with the model. However, except for commitment to the organization, regression analyses failed to double cross-validate either within or between samples.

BACKGROUND Evidence is accumulating that a cannabis withdrawal syndrome is common, of clinical significance, and has a clear time course. Up till now, very limited data exist on the cannabis withdrawal symptoms in patients with co-morbid substance use disorders, other than cannabis use and tobacco use. METHODS Symptoms of withdrawal were assessed through patient self-reports during detoxifica...

In this study, the effect of reversible inactivation of locus ceruleus (LC) on naloxone- induced withdrawal syndrome in paragigantocellular (PGi) neurons in morphine- dependent rats was investigated. For inactivation of LC, 1 µl of lidocaine (2%) was used and for induction of withdrawal syndrome, naloxone hydrochloride (2 mg/kg) was injected systemically. The results showed that in dependent gr...

objective: addiction, especially morphine dependence is a prevalence and incurable disease. with regard to low ability of new chemical drugs in treatment of addicted ones and with respect to herbal medicine recommendation due to lower side effects and cheap production. this study experimentally examined the effect of p.harmala on morphine withdrawal syndrome. materials and methods: animals wer...

background: the study was performed to investigate the effects of morphine dependency and morphine withdrawal on the reproductive system of adult male rat(wistar).  methods: 32 adult male rat divided into 5 groups. animals in the control group (n=8) received normal saline (1ml/kg) twice daily subcutaneously for 30 consecutive days. animals in dependent group (n=8) received morphine (10mg/ml/kg)...

Smoking is a widespread health problem. Because the nicotine withdrawal syndrome is a major contributor to continued smoking and relapse, it is important to understand the molecular and behavioral mechanisms of nicotine withdrawal to generate more effective smoking cessation therapies. Studies suggest a role for calcium-dependent mechanisms, such as L-type calcium channels and calcium/calmoduli...