Let {sij : i, j = 1, 2, . . . } consist of i.i.d. random variables in C with Es11 = 0, E|s11| = 1. For each positive integer N let sk = sk(N) = (s1k, s2k, . . . , sNk) , 1 ≤ k ≤ K, with K = K(N) and K/N → c > 0 as N → ∞. Assume for fixed positive integer L, for each N and k ≤ K αk = (αk(1), . . . , αk(L)) is random, independent of the sij , and the empirical distribution of (α1, . . . , αK), wi...

α-Thalassemia, arising from a defect in α-globin chain synthesis, is often caused by deletions involving one or both of the α-genes on the same allele. With the aim of investigating the prevalence of α-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, 713 unrelated individuals, between 18 and 59 years-of-age, were analyzed. Red blood cell indices were electronically de...

Objectives. Check with hematological data that the diagnosis and clinical grade of β-thalassemia intermedia can be established when a triplication genes alpha (αααanti 3.7) heterozygous are coherent. Methods. Retrospective study in which 73 patients Caucasian origin participated, who simultaneously showed tripling or quadrupling α β-thalassemia. Screening for most frequent α-thalassemia mutatio...

A family of four from the Guangxi Zhuang Autonomous Region of China, including a child with α-thalassaemia and hereditary spherocytosis (HS), underwent laboratory identification, and genetic analysis. After harvesting peripheral blood samples from the child patient and his family members, GAP-polymerase chain reaction (PCR) and reverse dot-blot tests were used to identify thalassaemia genotypes...

Although L-amino acids were selected as main constituents of peptides and proteins during chemical evolution, D-aspartyl (Asp) residue is found in a variety of living tissues. In particular, D-β-Asp is thought to be stable than any other Asp isomers, and this could be a reason for gradual accumulation in abnormal proteins and peptides to modify their structures and functions. It is predicted th...

Alpha thalassemia has not been systematically investigated in Brazil. In this study, 493 unrelated individuals from the southernmost Brazilian state of Rio Grande do Sul were screened for deletional forms of α-thalassemia. One hundred and one individuals had microcytic anemia (MCV < 80 fL) and a normal hemoglobin pattern (Hb A (2) < 3.5% and Hb F < 1%). The subjects were screened for - α(3.7) ,...

At low energies, few-body systems with large scattering length exhibit universal features (universality) that are independent of the interaction details. Some consequences are the existence of a shallow bound state and the Efimov effect1 in the twoand three-body sectors, respectively. These universal properties have a wide range of applications, from particle and nuclear to atomic and molecular...